Fitzmaurice Sarah, Eisen Daniel B
Department of Dermatology, University of California Davis, Sacramento, California.
Dermatol Surg. 2016 Mar;42(3):286-95. doi: 10.1097/DSS.0000000000000633.
Photodynamic therapy (PDT) has been used extensively to treat actinic keratoses (AKs) and less so nonmelanoma skin cancers (NMSC). Conventional in-office treatment is limited by intensive time requirements and patient discomfort. A new trend toward the use of daylight as a light source either clinically monitored or self-supervised is gaining acceptance.
To assess the current published data on daylight photodynamic therapy (dPDT) and identify knowledge gaps.
A systematic search of the PubMed archives using the terms daylight PDT, daylight-PDT, daylight photodynamic therapy, and ambient light and photodynamic therapy was conducted on May 18, 2015. No restrictions were used for the search string.
Seventeen published works were identified on the use of dPDT; 8 randomized studies, 4 prospective cohort studies, 1 case series, 1 case report, and 3 retrospective studies. Complete response rates for treatment of AKs from randomized trials range from 46% to 89.2%.
Daylight PDT has been demonstrated to have high efficacy with results similar to conventional PDT for the treatment of AKs. Initial reports regarding treatment of NMSC indicate recurrence rates much higher than other accepted therapies. Pain associated with treatment seems to be significantly less than for conventional PDT.
光动力疗法（PDT）已被广泛用于治疗光化性角化病（AK），而用于治疗非黑色素瘤皮肤癌（NMSC）的情况较少。传统的门诊治疗受到时间要求高和患者不适的限制。一种新趋势是使用日光作为光源，无论是临床监测还是自我监督，这种趋势正在被接受。
评估目前已发表的关于日光光动力疗法（dPDT）的数据，并找出知识空白。
于2015年5月18日在PubMed数据库中使用“日光PDT”“日光 - PDT”“日光光动力疗法”以及“环境光与光动力疗法”等术语进行系统检索。检索词没有限制。
共识别出17篇关于使用dPDT的已发表文献；8项随机研究、4项前瞻性队列研究、1项病例系列研究、1项病例报告和3项回顾性研究。随机试验中治疗AK的完全缓解率在46%至89.2%之间。
日光光动力疗法已被证明具有高效性，治疗AK的效果与传统PDT相似。关于NMSC治疗的初步报告表明复发率远高于其他公认疗法。与治疗相关的疼痛似乎明显低于传统PDT。
