Figueroa C D, MacIver A G, Dieppe P, Mackenzie J C, Bhoola K D
Department of Pharmacology, Medical School, University of Bristol, England.
Adv Exp Med Biol. 1989;247B:207-10. doi: 10.1007/978-1-4615-9546-5_34.
The presence of tissue kallikrein in polymorphonuclear (PMN) leucocytes from normal human blood and from patients with rheumatoid arthritis and pyelonephritis was investigated. Immunoreactive tissue kallikrein was specifically detected in neutrophil leucocytes. PMN leucocytes displayed a granular staining. In the synovial membrane and kidney, the cells were aggregated into pockets as part of an inflammatory infiltrate. The presence of immunoreactive tissue kallikrein in human PMN leucocytes may provide a new insight into the importance of this enzyme in inflammation.
对来自正常人血液、类风湿性关节炎患者和肾盂肾炎患者的多形核（PMN）白细胞中组织激肽释放酶的存在情况进行了研究。在中性粒细胞中特异性检测到免疫反应性组织激肽释放酶。PMN白细胞呈现颗粒状染色。在滑膜和肾脏中，这些细胞聚集成小簇，作为炎症浸润的一部分。人类PMN白细胞中免疫反应性组织激肽释放酶的存在可能为该酶在炎症中的重要性提供新的见解。
