Shields Laurence E, Wiesner Suzanne, Klein Catherine, Pelletreau Barbara, Hedriana Herman L
Maternal Fetal Medicine, Marian Regional Medical Center, Santa Maria, CA; Department of Patient Safety, Dignity Health, San Francisco, CA.
Department of Patient Safety, Dignity Health, San Francisco, CA.
Am J Obstet Gynecol. 2016 Apr;214(4):527.e1-527.e6. doi: 10.1016/j.ajog.2016.01.154. Epub 2016 Feb 28.
Maternal mortality in the United States has increased unabated for the past 20 years. Maternal morbidity is also affecting an increasingly large number of women in the United States. A number of national and state organizations have recommend the use of maternal early warning tools as a method to combat this problem. There are limited data suggesting that the use of these types of clinical assessment tools can reduce maternal morbidity.
We sought to determine if maternal morbidity could be reduced with the implementation of a clinical pathway-specific Maternal Early Warning Trigger (MEWT) tool.
The tool was developed internally and prospectively implemented as a pilot project in 6 of 29 hospitals within a large hospital system. The primary goal was early assessment and treatment of patients suspected of clinical deterioration. The tool addressed the 4 most common areas of maternal morbidity: sepsis, cardiopulmonary dysfunction, preeclampsia-hypertension, and hemorrhage. To be considered positive, triggers needed to be sustained for >20 minutes and were defined as severe (single abnormal value): maternal heart rate (HR) >130 beats/min (bpm), respiratory rate >30/min, mean arterial pressure <55 mm Hg, oxygen saturation <90%, or nurse concern; or nonsevere (required 2 abnormal values): temperature >38 or <36°C, blood pressure >160/110 or <85/45 mm Hg, HR >110 or <50 bpm, respiratory rate >24 or <10/min, oxygen saturation <93%, fetal HR >160 bpm, altered mental status, or disproportionate pain. Within each group, recommended management or assessment was also provided. Outcome measures were Centers for Disease Control and Prevention (CDC)-defined severe maternal morbidity, composite maternal morbidity, and intensive care unit (ICU) admissions. Two time intervals were used to analyze the effect of the MEWT tool: a 24-month baseline control period and a 13-month MEWT study period. To determine that the findings noted were not simply changes that would have occurred without the utilization of the early warning tool, we also compared a control population from nonpilot sites during the same baseline and 13-month time periods.
There were 36,832 deliveries at the pilot sites (24,221 pre- and 12,611 post-MEWT testing) and 146,359 at the nonpilot sites (95,718 pre- and 50,641 post-MEWT testing) during the 2 study time periods. Use of the MEWT tool resulted in significant reductions in CDC severe maternal morbidity (P < 0.01) and composite morbidity (P < 0.01). ICU admissions were unchanged. At nonpilot sites CDC severe maternal morbidity, composite morbidity, and ICU admissions were unchanged between baseline and the post-MEWT testing time period.
The use of the MEWT tool in this study, designed to address 4 of the most common causes of maternal morbidity, as well as provide assessment and management recommendations, resulted in significant improvement in maternal morbidity. The variation in hospital delivery services at the pilot sites suggests that this maternal early warning tool would be suitable for use in the majority of maternity centers in the United States.
在过去20年里,美国孕产妇死亡率持续上升。孕产妇发病率也影响着越来越多的美国女性。许多国家和州级组织建议使用孕产妇早期预警工具来解决这一问题。仅有有限的数据表明,使用这类临床评估工具可降低孕产妇发病率。
我们试图确定实施特定临床路径的孕产妇早期预警触发(MEWT)工具是否能降低孕产妇发病率。
该工具由内部开发,并作为试点项目前瞻性地在一个大型医院系统的29家医院中的6家实施。主要目标是对疑似临床病情恶化的患者进行早期评估和治疗。该工具涉及孕产妇发病最常见的4个领域:败血症(脓毒症)、心肺功能障碍、先兆子痫 - 高血压和出血。若要判定为阳性,触发情况需持续超过20分钟,并定义为严重(单一异常值):孕产妇心率(HR)>130次/分钟(bpm)、呼吸频率>30次/分钟、平均动脉压<55毫米汞柱、血氧饱和度<90%,或护士关注;或非严重(需要2个异常值):体温>38或<36°C、血压>160/110或<85/45毫米汞柱、HR>110或<50 bpm、呼吸频率>24或<10次/分钟、血氧饱和度<93%、胎儿心率>160 bpm、精神状态改变或疼痛异常。在每组中,还提供了推荐的管理或评估措施。结局指标为疾病控制与预防中心(CDC)定义的严重孕产妇发病率、综合孕产妇发病率和重症监护病房(ICU)入院情况。使用两个时间间隔来分析MEWT工具的效果:24个月的基线对照期和13个月的MEWT研究期。为确定所观察到的结果并非仅仅是在未使用早期预警工具情况下也会发生的变化,我们还比较了同一基线期和13个月时间段内非试点医院的对照人群。
在两个研究时间段内,试点医院有36,832例分娩(MEWT测试前24,221例,测试后12,611例),非试点医院有146,359例分娩(MEWT测试前95,718例,测试后50,641例)。使用MEWT工具使CDC定义的严重孕产妇发病率(P < 0.01)和综合发病率(P < 0.01)显著降低。ICU入院率未变。在非试点医院,CDC定义的严重孕产妇发病率、综合发病率和ICU入院率在基线期和MEWT测试后时间段之间未发生变化。
本研究中使用的MEWT工具旨在解决孕产妇发病的4个最常见原因,并提供评估和管理建议,显著改善了孕产妇发病率。试点医院分娩服务的差异表明,这种孕产妇早期预警工具适用于美国大多数产科中心。