Catalfo Giuseppe, Crea Luciana, Lo Castro Tiziana, Magnano San Lio Francesca, Minutolo Giuseppe, Siscaro Gherardo, Vaccino Noemi, Crimi Nunzio, Aguglia Eugenio
Department of Psychiatry, Policlinico "G. Rodolico" University Hospital, University of Catania, Catania, Italy.
Operative Unit Neurorehabilitation, IRCCS Fondazione Salvatore Maugeri, Sciacca, Italy.
Int J Chron Obstruct Pulmon Dis. 2016 Feb 4;11:239-49. doi: 10.2147/COPD.S84347. eCollection 2016.
Several clinical studies suggest common underlying pathogenetic mechanisms of COPD and depressive/anxiety disorders. We aim to evaluate psychopathological and physical effects of aerobic exercise, proposed in the context of pulmonary rehabilitation, in a sample of COPD patients, through the correlation of some psychopathological variables and physical/pneumological parameters.
Fifty-two consecutive subjects were enrolled. At baseline, the sample was divided into two subgroups consisting of 38 depression-positive and 14 depression-negative subjects according to the Hamilton Depression Rating Scale (HAM-D). After the rehabilitation treatment, we compared psychometric and physical examinations between the two groups.
The differences after the rehabilitation program in all assessed parameters demonstrated a significant improvement in psychiatric and pneumological conditions. The reduction of BMI was significantly correlated with fat mass but only in the depression-positive patients.
Our results suggest that pulmonary rehabilitation improves depressive and anxiety symptoms in COPD. This improvement is significantly related to the reduction of fat mass and BMI only in depressed COPD patients, in whom these parameters were related at baseline. These findings suggest that depressed COPD patients could benefit from a rehabilitation program in the context of a multidisciplinary approach.
多项临床研究表明慢性阻塞性肺疾病（COPD）与抑郁/焦虑障碍存在共同的潜在发病机制。我们旨在通过一些心理病理学变量与身体/肺科参数的相关性，评估在肺康复背景下进行的有氧运动对COPD患者样本的心理病理学和身体影响。
连续纳入52名受试者。在基线时，根据汉密尔顿抑郁量表（HAM-D）将样本分为两个亚组，分别为38名抑郁阳性受试者和14名抑郁阴性受试者。康复治疗后，我们比较了两组之间的心理测量和身体检查结果。
康复计划后所有评估参数的差异表明，精神和肺部状况有显著改善。体重指数（BMI）的降低与脂肪量显著相关，但仅在抑郁阳性患者中如此。
我们的结果表明，肺康复可改善COPD患者的抑郁和焦虑症状。这种改善仅在抑郁的COPD患者中与脂肪量和BMI的降低显著相关，在这些患者中，这些参数在基线时是相关的。这些发现表明，抑郁的COPD患者可以从多学科方法背景下的康复计划中获益。
