Soriano Sergi, Ripoll Cristina, Alonso-Magdalena Paloma, Fuentes Esther, Quesada Ivan, Nadal Angel, Martinez-Pinna Juan
Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Spain.
Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universidad Miguel Hernández de Elche, Spain.
Steroids. 2016 Jul;111:12-20. doi: 10.1016/j.steroids.2016.02.020. Epub 2016 Feb 27.
Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) produced in huge quantities in the manufacture of polycarbonate plastics and epoxy resins. It is present in most humans in developed countries, acting as a xenoestrogen and it is considered an environmental risk factor associated to several diseases. Among the whole array of identified mechanisms by which BPA can interfere with physiological processes in living organisms, changes on ion channel activity is one of the most poorly understood. There is still little evidence about BPA regulation of ion channel expression and function. However, this information is key to understand how BPA disrupts excitable and non-excitable cells, including neurons, endocrine cells and muscle cells. This report is the result of a comprehensive literature review on the effects of BPA on ion channels. We conclude that there is evidence to say that these important molecules may be key end-points for EDCs acting as xenoestrogens. However, more research on channel-mediated BPA effects is needed. Particularly, mechanistic studies to unravel the pathophysiological actions of BPA on ion channels at environmentally relevant doses.
双酚A（BPA）是一种内分泌干扰化学物质（EDC），在聚碳酸酯塑料和环氧树脂的制造过程中大量生产。在发达国家，大多数人体内都有这种物质，它作为一种外源性雌激素发挥作用，被认为是与多种疾病相关的环境风险因素。在已确定的双酚A干扰生物体生理过程的所有机制中，离子通道活性的变化是了解最少的机制之一。关于双酚A对离子通道表达和功能的调节，目前仍缺乏证据。然而，这些信息对于理解双酚A如何破坏可兴奋细胞和非可兴奋细胞（包括神经元、内分泌细胞和肌肉细胞）至关重要。本报告是对双酚A对离子通道影响的全面文献综述的结果。我们得出结论，有证据表明这些重要分子可能是作为外源性雌激素的内分泌干扰化学物质的关键终点。然而，需要对通道介导的双酚A效应进行更多研究。特别是，需要进行机制研究，以揭示环境相关剂量下双酚A对离子通道的病理生理作用。
