Zhuo Junjie, Fan Lingzhong, Liu Yong, Zhang Yuanchao, Yu Chunshui, Jiang Tianzi
Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, Peoples' Republic of China.
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, Peoples' Republic of China, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, Peoples' Republic of China.
J Neurosci. 2016 Mar 2;36(9):2782-95. doi: 10.1523/JNEUROSCI.1975-15.2016.
Traditional anatomical studies of the parahippocampal region (PHR) defined the lateral portion into two subregions, the perirhinal (PRC) and parahippocampal (PHC) cortices. Based on this organization, several models suggested that the PRC and the PHC play different roles in memory through connections with different memory-related brain networks. To identify the key components of the human PHR, we used a well accepted connection-based parcellation method on two independent datasets. Our parcellation divided the PRC and PHC into three subregions, specifically, the rostral PRC, caudal PRC (PRCc), and PHC. The connectivity profile for each subregion showed that the rostral PRC was connected to the anterior temporal (AT) system and the PHC was connected to the posterior medial (PM) system. The transition area (PRCc) integrated the AT-PM systems. These results suggest that the lateral PHR not only contains functionally segregated subregions, but also contains a functionally integrated subregion.
We redefined the cartography of the human parahippocampal region (PHR) and identified a transition subarea based on distinct anatomical and functional connectivity profiles. This well defined anatomical organization of the PHR is necessary for expanding our understanding and studying the functional relevance of its subregions in recognition memory. We found that the transition subregion [caudal perirhinal cortex (PRCc)] is a functionally integrated subregion that integrates the anterior temporal (AT)-posterior medial (PM) systems. In addition, we found that the core components of the AT and PM systems connect with the PHR in the rostral PRC and parahippocampal cortex (PHC), respectively, rather than connecting with the traditional, larger, and thus less concise PRC and PHC areas. This may lead to new insights into the human memory system and related neurodegenerative diseases.
传统的海马旁区域（PHR）解剖学研究将其外侧部分划分为两个亚区域，即嗅周皮质（PRC）和海马旁皮质（PHC）。基于这种结构，一些模型表明，PRC和PHC通过与不同的记忆相关脑网络的连接在记忆中发挥不同作用。为了确定人类PHR的关键组成部分，我们在两个独立的数据集中使用了一种广泛接受的基于连接的脑区划分方法。我们的划分将PRC和PHC分为三个亚区域，具体为吻侧PRC、尾侧PRC（PRCc）和PHC。每个亚区域的连接图谱显示，吻侧PRC与颞前（AT）系统相连，PHC与后内侧（PM）系统相连。过渡区域（PRCc）整合了AT-PM系统。这些结果表明，外侧PHR不仅包含功能上分离的亚区域，还包含一个功能上整合的亚区域。
我们重新定义了人类海马旁区域（PHR）的图谱，并基于不同的解剖和功能连接图谱确定了一个过渡子区域。这种明确界定的PHR解剖结构对于扩展我们对其亚区域在识别记忆中的功能相关性的理解和研究至关重要。我们发现过渡子区域[尾侧嗅周皮质（PRCc）]是一个功能上整合的亚区域，它整合了颞前（AT）-后内侧（PM）系统。此外，我们发现AT和PM系统的核心组件分别与吻侧PRC和海马旁皮质（PHC）中的PHR相连，而不是与传统的、更大且因此不太精确的PRC和PHC区域相连。这可能会为人类记忆系统和相关神经退行性疾病带来新的见解。
