Chen Yi, Ni Bingqian, Yang Chaoyu, Pan Jingjing, Zhang Jinshun
Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.
Department of Otolaryngology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.
Front Cardiovasc Med. 2024 Oct 24;11:1476435. doi: 10.3389/fcvm.2024.1476435. eCollection 2024.
Cardiovascular disease significantly impacts human health. The development of carotid plaques elevates the risk of cardiovascular disease, while the influence of Helicobacter pylori (H. pylori) on carotid plaques remains a subject of debate. This study aimed to investigate the association between H. pylori infection and carotid plaque using a cohort study.
The study included individuals who underwent multiple physical examinations at the Health Examination Center of Taizhou Hospital. The relationship between H. pylori and carotid plaque was explored using multifactorial logistic regression analysis. Participants were categorized into groups based on their H. pylori infection status at the initial and final examinations, comprising persistent infection, persistent negative, new infection, and eradication infection, to analyze variations in carotid plaque prevalence among these groups.
In both univariate and multifactorial regression analyses, H. pylori was identified as a risk factor for carotid plaque development. Moreover, when compared to the persistent negative group, both the new infection and persistent infection groups showed a notable increase in the risk of carotid plaque. Additionally, individuals in the persistent infection group exhibited higher blood pressure and blood glucose levels than those in the persistent negative group. Likewise, there was a discrepancy in the impact of insulin resistance on carotid plaque between the H. pylori positive and negative groups.
H. pylori is a risk factor for carotid plaque, with a long-term infection associated with an increased risk of carotid plaque formation. In addition, H. pylori promoting carotid plaque formation may be related to blood pressure, blood glucose, and insulin resistance.
心血管疾病对人类健康有重大影响。颈动脉斑块的形成会增加心血管疾病的风险，而幽门螺杆菌（H. pylori）对颈动脉斑块的影响仍存在争议。本研究旨在通过队列研究探讨幽门螺杆菌感染与颈动脉斑块之间的关联。
该研究纳入了在台州医院健康体检中心接受多次体检的个体。采用多因素逻辑回归分析探讨幽门螺杆菌与颈动脉斑块之间的关系。根据参与者在初次和末次检查时的幽门螺杆菌感染状况将其分为持续感染、持续阴性、新感染和根除感染组，以分析这些组中颈动脉斑块患病率的变化。
在单因素和多因素回归分析中，幽门螺杆菌均被确定为颈动脉斑块形成的危险因素。此外，与持续阴性组相比，新感染组和持续感染组的颈动脉斑块风险均显著增加。此外，持续感染组个体的血压和血糖水平高于持续阴性组。同样，幽门螺杆菌阳性和阴性组之间胰岛素抵抗对颈动脉斑块的影响也存在差异。
幽门螺杆菌是颈动脉斑块的危险因素，长期感染会增加颈动脉斑块形成的风险。此外，幽门螺杆菌促进颈动脉斑块形成可能与血压、血糖和胰岛素抵抗有关。
