Cao Wen-Wen, Luo Qi, Cheng Yong-Xian, Wang Shu-Mei
Guangdong Pharmaceutical University, Guangzhou 510006, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Yuquan Road 19, Beijing 100049, PR China.
Fitoterapia. 2016 Apr;110:110-5. doi: 10.1016/j.fitote.2016.03.003. Epub 2016 Mar 3.
Zizhines A-F (1-6), six pairs of new meroterpenoid enantiomers and a known meroterpenoid (7) were isolated from the fruiting bodies of Ganoderma sinensis. The structures and absolute configurations of the new substances were assigned by spectroscopic and computational methods. All the compounds apart from 7 were evaluated for their inhibition on extracellular matrix component (fibronectin) generation by using TGF-β1-induced rat kidney tubular epithelial cells. Although none of them was found to be active in these cells, the present findings add new facets for the chemistry of Ganoderma.
从赤芝子实体中分离得到了紫芝素A - F（1 - 6）、六对新的半萜类对映体以及一种已知的半萜类化合物（7）。通过光谱和计算方法确定了新物质的结构和绝对构型。除化合物7外，所有化合物均利用转化生长因子β1诱导的大鼠肾小管上皮细胞，评估了它们对细胞外基质成分（纤连蛋白）生成的抑制作用。尽管在这些细胞中未发现它们具有活性，但目前的研究结果为灵芝化学增添了新的内容。
