Luo Qi, Di Lei, Dai Wei-Feng, Lu Qing, Yan Yong-Ming, Yang Zhu-Liang, Li Rong-Tao, Cheng Yong-Xian
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany and ∥Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, P. R. China.
Org Lett. 2015 Mar 6;17(5):1110-3. doi: 10.1021/ol503610b. Epub 2015 Feb 23.
Applanatumin A (1), a novel meroterpenoid dimer, was isolated from the fungus Ganoderma applanatum. Its structure and absolute configuration were assigned on the basis of spectroscopic and computational data. Notably, 1 possesses a new hexacyclic skeleton containing a spiro[benzofuran-2,1'-cyclopentane] motif. A plausible pathway, involving a key Diels-Alder reaction, is proposed for the biosynthesis of 1. Applanatumin A exhibits potent antifibrotic activity in TGF-β1-induced human renal proximal tubular cells.
扁芝素A（1）是一种新型的半萜二聚体，从真菌扁芝中分离得到。其结构和绝对构型是根据光谱和计算数据确定的。值得注意的是，1具有一个包含螺[苯并呋喃-2,1'-环戊烷]基序的新的六环骨架。提出了一条涉及关键狄尔斯-阿尔德反应的可能的生物合成途径来合成1。扁芝素A在转化生长因子-β1诱导的人肾近端小管细胞中表现出强大的抗纤维化活性。
