Aydemir Nihan, Malmström Jenny, Travas-Sejdic Jadranka
Polymer Electronics Research Centre, School of Chemical Sciences, University of Auckland, New Zealand.
Phys Chem Chem Phys. 2016 Mar 28;18(12):8264-77. doi: 10.1039/c5cp06830d.
Conducting polymer (CP)-based electrochemical biosensors have gained great attention as such biosensor platforms are easy and cost-effective to fabricate, and provide a direct electrical readout for the presence of biological analytes with high sensitivity and selectivity. CP materials themselves are both sensing elements and transducers of the biological recognition event at the same time, simplifying sensor designs. This review summarizes the advances in electrochemical biosensors based on CPs. Recognition probe immobilisation techniques, transduction mechanisms and detection of various target biomolecules have been discussed in detail. Efforts to miniaturize CP-based electrochemical biosensors and fabrication of sensor arrays are also briefly reviewed.
基于导电聚合物(CP)的电化学生物传感器备受关注,因为此类生物传感器平台易于制造且成本效益高,能以高灵敏度和选择性对生物分析物的存在进行直接电学读出。CP材料本身同时既是传感元件又是生物识别事件的换能器,简化了传感器设计。本综述总结了基于CP的电化学生物传感器的进展。详细讨论了识别探针固定技术、转换机制以及各种目标生物分子的检测。还简要回顾了使基于CP的电化学生物传感器小型化的努力以及传感器阵列的制造。