Sedigh-Shams Mahdi, Badiee Parisa, Adl Alireza, Sarab Milad Dadollahi, Abbaszadegan Abbas, Nabavizadeh Mohammadreza
Department of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Mycology, Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
J Conserv Dent. 2016 Jan-Feb;19(1):101-5. doi: 10.4103/0972-0707.173212.
This study compared the antifungal effect of Zataria multiflora essential oil (EO) with that of sodium hypochlorite (NaOCl) as an irrigant for root canals infected with Candida albicans.
Sixty mandibular premolars were infected with C. albicans suspension. After 72 h of incubation, the samples were divided into four groups. Teeth in Group 1 were irrigated with minimum fungicidal concentration (MFC) of Z. multiflora EO, in Group 2 with twice the MFC of Z. multiflora, in Group 3 with MFC of NaOCl, and in Group 4 with distilled water (DW). Pre- and post-operative samples were cultured, and fungal colony count of each specimen was obtained. Data were analyzed using Kruskal-Wallis and Mann-Whitney tests (P < 0.05).
NaOCl at MFC and Z. multiflora EO at twice the MFC showed the highest antifungal efficacy, with no significant difference (P > 0.05). However, antifungal efficacies of these irrigants were significantly different from those of Z. multiflora EO at MFC and DW (P < 0.05).
Our results showed that Z. multiflora EO at twice the MFC had the same antifungal efficacy as NaOCl at MFC.
本研究比较了百里香精油（EO）与次氯酸钠（NaOCl）作为白色念珠菌感染根管冲洗剂的抗真菌效果。
60颗下颌前磨牙感染白色念珠菌悬液。培养72小时后，将样本分为四组。第1组牙齿用百里香EO的最低杀菌浓度（MFC）冲洗，第2组用两倍MFC的百里香冲洗，第3组用NaOCl的MFC冲洗，第4组用蒸馏水（DW）冲洗。对术前和术后样本进行培养，获得每个标本的真菌菌落计数。使用Kruskal-Wallis和Mann-Whitney检验分析数据（P < 0.05）。
MFC的NaOCl和两倍MFC的百里香EO显示出最高的抗真菌效果，无显著差异（P > 0.05）。然而，这些冲洗剂的抗真菌效果与MFC的百里香EO和DW的抗真菌效果有显著差异（P < 0.05）。
我们的结果表明，两倍MFC的百里香EO与MFC的NaOCl具有相同的抗真菌效果。
