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根瘤菌苷，一种来自根瘤菌共生体慢生根瘤菌属BTAi1的鼠李糖脂 - 氨基醇杂合物。

Rhizoleucinoside, a Rhamnolipid-Amino Alcohol Hybrid from the Rhizobial Symbiont Bradyrhizobium sp. BTAi1.

作者信息

Chen Jianwei, Sun Jiadong, Deering Robert W, DaSilva Nicholas, Seeram Navindra P, Wang Hong, Rowley David C

机构信息

College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou, Zhejiang 310014, China.

Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island , Kingston, Rhode Island 02881, United States.

出版信息

Org Lett. 2016 Mar 18;18(6):1490-3. doi: 10.1021/acs.orglett.6b00461. Epub 2016 Mar 9.

DOI:10.1021/acs.orglett.6b00461
PMID:26959412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5818987/
Abstract

Rhizoleucinoside (1), a unique rhamnolipid-amino alcohol hybrid, was isolated from the rhizobial symbiont bacterium Bradyrhizobium sp. BTAi1. Compound 1 features a rare rhamnolipid core attached to an unprecedented leucinol moiety. Its structure and absolute configuration were determined by spectroscopic analysis, tandem mass spectrometry, chemical degradation, and application of the Marfey's method. Compound 1 possesses moderate cytotoxicity to BV-2 murine microglia and highly aggressive proliferating immortalized (HAPI) rat microglia cells.

摘要

根瘤菌亮氨酸苷（1）是一种独特的鼠李糖脂 - 氨基醇杂合物，从根瘤菌共生细菌慢生根瘤菌属BTAi1中分离得到。化合物1具有一个罕见的鼠李糖脂核心，连接着一个前所未有的亮氨醇部分。其结构和绝对构型通过光谱分析、串联质谱、化学降解以及马尔费方法确定。化合物1对BV - 2小鼠小胶质细胞和高度侵袭性增殖永生化（HAPI）大鼠小胶质细胞具有中等细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/5818987/77dba583ab6a/nihms941339f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/5818987/64375b6097a4/nihms941339f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/5818987/2c6373eca644/nihms941339f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/5818987/77dba583ab6a/nihms941339f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/5818987/64375b6097a4/nihms941339f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/5818987/2c6373eca644/nihms941339f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b768/5818987/77dba583ab6a/nihms941339f3.jpg

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