Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China.
Haikou Key Laboratory for Research and Development of Tropical Natural Products, Haikou 571101, Hainan, China.
Mar Drugs. 2012 Mar;10(3):598-603. doi: 10.3390/md10030598. Epub 2012 Mar 6.
To study the antimicrobial components from the endophytic fungus A1 of mangrove plant Scyphiphora hydrophyllacea Gaertn. F., a new fatty acid glucoside was isolated by column chromatography from the broth of A1, and its structure was identified as R-3-hydroxyundecanoic acid methylester-3-O-α-l-rhamnopyranoside (1) by spectroscopic methods including 1D and 2D NMR (HMQC, (1)H-(1)H COSY and HMBC) and chemical methods. Antimicrobial assay showed compound 1 possessed modest inhibitory effect on Saphylococcus aureus and methicillin-resistant S. aureus (MRSA) using the filter paper disc agar diffusion method.
为了研究红树植物海桑 Scyphiphora hydrophyllacea Gaertn. F. 内生真菌 A1 的抗菌成分，通过柱色谱法从 A1 的发酵液中分离得到一种新的脂肪酸葡萄糖苷，通过包括 1D 和 2D NMR (HMQC、(1)H-(1)H COSY 和 HMBC) 和化学方法在内的光谱方法鉴定其结构为 R-3-羟基十一烷酸甲酯-3-O-α-l-鼠李吡喃糖苷（1）。抑菌试验表明，化合物 1 采用滤纸圆盘琼脂扩散法对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌（MRSA）具有中等抑制作用。
