Crémieux A, Reverdy M E, Pons J L, Savage C, Chevalier J, Fleurette J, Mossé M
Laboratoire de Microbiologie, Hygiène Microbienne, Immunologie, Faculté de Pharmacie, Marseille, France.
Appl Environ Microbiol. 1989 Nov;55(11):2944-8. doi: 10.1128/aem.55.11.2944-2948.1989.
A standardized protocol for the evaluation of hand disinfection by surgical scrub formulations was applied to volunteers in a multicenter trial. Povidone iodine (PVI), chlorhexidine (CHX), and a nonmedicated soap (NMS) were tested. The scrubbing procedure involved three daily hand washings for five consecutive days; surviving bacteria were counted daily after being collected in a suitable neutralizing solution. Immediate efficacy (IE), cumulative efficacy (CE), and remanent effect (RE) were calculated by reference to the control hand. Statistical analyses of IE, CE, and RE showed significant differences among the three scrub formulations. IEs of PVI and CHX were equivalent and different from IE of NMS; CE and RE of CHX were higher than those of PVI and NMS. On the basis of the statistical analysis, the population size required for further studies aimed at detecting significant differences between surgical scrub formulations could be estimated.
在一项多中心试验中，将一种用于评估手术擦洗制剂手部消毒效果的标准化方案应用于志愿者。对聚维酮碘（PVI）、洗必泰（CHX）和一种无药肥皂（NMS）进行了测试。擦洗程序包括连续五天每天洗手三次；每天在收集于合适中和溶液中的细菌存活情况进行计数。通过参照对照手计算即时疗效（IE）、累积疗效（CE）和残留效应（RE）。对IE、CE和RE的统计分析表明，三种擦洗制剂之间存在显著差异。PVI和CHX的IE相当，且与NMS的IE不同；CHX的CE和RE高于PVI和NMS。基于统计分析，可以估计旨在检测手术擦洗制剂之间显著差异的进一步研究所需的样本量。
