Krupic Julija, Bauza Marius, Burton Stephen, O'Keefe John
Department of Cell and Developmental Biology, University College London, London, WC1E 6BT, UK.
Sainsbury Wellcome Centre, University College London, London, WC1E 6BT, UK.
J Physiol. 2016 Nov 15;594(22):6489-6499. doi: 10.1113/JP270607. Epub 2016 May 10.
Cells in the mammalian hippocampal formation subserve neuronal representations of environmental location and support navigation in familiar environments. Grid cells constitute one of the main cell types in the hippocampal formation and are widely believed to represent a universal metric of space independent of external stimuli. Recent evidence showing that grid symmetry is distorted in non-symmetrical environments suggests that a re-examination of this hypothesis is warranted. In this review we will discuss behavioural and physiological evidence for how environmental shape and in particular enclosure boundaries influence grid cell firing properties. We propose that grid cells encode the geometric layout of enclosures.
哺乳动物海马结构中的细胞有助于对环境位置进行神经元表征，并支持在熟悉环境中的导航。网格细胞是海马结构中的主要细胞类型之一，人们普遍认为它们代表了一种独立于外部刺激的通用空间度量。最近有证据表明，在非对称环境中网格对称性会受到扭曲，这表明有必要重新审视这一假设。在这篇综述中，我们将讨论行为和生理学证据，以说明环境形状，特别是封闭边界如何影响网格细胞的放电特性。我们提出，网格细胞对封闭空间的几何布局进行编码。
