Bronner Marianne E, Simões-Costa Marcos
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
Curr Top Dev Biol. 2016;116:115-34. doi: 10.1016/bs.ctdb.2015.12.003. Epub 2016 Jan 23.
From the initial discovery of the neural crest over 150 years ago to the seminal studies of Le Douarin and colleagues in the latter part of the twentieth century, understanding of the neural crest has moved from the descriptive to the experimental. Now, in the twenty-first century, neural crest research has migrated into the genomic age. Here, we reflect upon the major advances in neural crest biology and the open questions that will continue to make research on this incredible vertebrate cell type an important subject in developmental biology for the century to come.
从150多年前神经嵴的最初发现，到20世纪后期勒杜兰及其同事的开创性研究，对神经嵴的理解已从描述性阶段进入实验性阶段。如今，在21世纪，神经嵴研究已迈入基因组时代。在此，我们回顾神经嵴生物学的主要进展以及一些尚未解决的问题，这些问题将继续使对这种神奇的脊椎动物细胞类型的研究在未来一个世纪成为发育生物学中的重要课题。
