围产期的细胞因子 - 第一部分

Cytokines in the perinatal period - Part I.

作者信息

Chau A, Markley J C, Juang J, Tsen L C

机构信息

Division of Obstetric Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada.

Division of Obstetric Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Anesthesia and Perioperative Care, San Francisco General Hospital, University of California San Francisco, San Francisco, CA USA.

出版信息

Int J Obstet Anesth. 2016 May;26:39-47. doi: 10.1016/j.ijoa.2015.12.005. Epub 2016 Jan 5.

DOI:10.1016/j.ijoa.2015.12.005

PMID:26970932

Abstract

Successful pregnancy requires a state of immune homeostasis. Maternal tolerance of the genetically distinct fetoplacental unit is in part mediated by maternal and fetal pro- and anti-inflammatory cytokines; these cytokines have also been implicated in different pregnancy-related pathologic states. This two-part series seeks to provide anesthesiologists with an overview on selected perinatal cytokines in an effort to identify opportunities for research and improvements in clinical care. In part one, we review basic and pregnancy-related elements of the immune system, with an emphasis on the role of cytokines. From this foundation, we offer a perspective of a unique phenomenon witnessed within obstetric anesthesia - maternal temperature elevation associated with labor epidural analgesia.

摘要

成功妊娠需要免疫稳态。母体对基因不同的胎儿 - 胎盘单位的耐受部分由母体和胎儿的促炎和抗炎细胞因子介导；这些细胞因子也与不同的妊娠相关病理状态有关。这个两部分系列旨在为麻醉医生提供关于选定围产期细胞因子的概述，以努力确定研究机会和改善临床护理。在第一部分中，我们回顾免疫系统的基本和与妊娠相关的要素，重点是细胞因子的作用。基于此基础，我们探讨产科麻醉中所见证的一种独特现象——与分娩硬膜外镇痛相关的母体体温升高。