Kosaka Nobuyoshi, Yoshioka Yusuke, Fujita Yu, Ochiya Takahiro
J Clin Invest. 2016 Apr 1;126(4):1163-72. doi: 10.1172/JCI81130. Epub 2016 Mar 14.
Numerous studies have shown that non-cell-autonomous regulation of cancer cells is an important aspect of tumorigenesis. Cancer cells need to communicate with stromal cells by humoral factors such as VEGF, FGFs, and Wnt in order to survive. Recently, extracellular vesicles (EVs) have also been shown to be involved in cell-cell communication between cancer cells and the surrounding microenvironment and to be important for the development of cancer. In addition, these EVs contain small noncoding RNAs, including microRNAs (miRNAs), which contribute to the malignancy of cancer cells. Here, we provide an overview of current research on EVs, especially miRNAs in EVs. We also propose strategies to treat cancers by targeting EVs around cancer cells.
众多研究表明，癌细胞的非细胞自主调节是肿瘤发生的一个重要方面。癌细胞需要通过VEGF、FGFs和Wnt等体液因子与基质细胞进行通讯以存活。最近，细胞外囊泡（EVs）也被证明参与癌细胞与周围微环境之间的细胞间通讯，并且对癌症发展至关重要。此外，这些EVs包含小的非编码RNA，包括微小RNA（miRNAs），它们有助于癌细胞的恶性发展。在此，我们概述了当前关于EVs的研究，特别是EVs中的miRNAs。我们还提出了通过靶向癌细胞周围的EVs来治疗癌症的策略。
