利用脂肪干细胞开发用于组织工程应用的合成材料和天然材料
Development of Synthetic and Natural Materials for Tissue Engineering Applications Using Adipose Stem Cells.
作者信息
He Yunfan, Lu Feng
机构信息
Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
出版信息
Stem Cells Int. 2016;2016:5786257. doi: 10.1155/2016/5786257. Epub 2016 Feb 10.
Abstract
Adipose stem cells have prominent implications in tissue regeneration due to their abundance and relative ease of harvest from adipose tissue and their abilities to differentiate into mature cells of various tissue lineages and secrete various growth cytokines. Development of tissue engineering techniques in combination with various carrier scaffolds and adipose stem cells offers great potential in overcoming the existing limitations constraining classical approaches used in plastic and reconstructive surgery. However, as most tissue engineering techniques are new and highly experimental, there are still many practical challenges that must be overcome before laboratory research can lead to large-scale clinical applications. Tissue engineering is currently a growing field of medical research; in this review, we will discuss the progress in research on biomaterials and scaffolds for tissue engineering applications using adipose stem cells.
摘要
脂肪干细胞因其数量丰富、相对易于从脂肪组织中获取，以及能够分化为各种组织谱系的成熟细胞并分泌多种生长细胞因子，在组织再生中具有重要意义。将组织工程技术与各种载体支架和脂肪干细胞相结合，在克服整形外科和重建外科中传统方法所存在的局限性方面具有巨大潜力。然而，由于大多数组织工程技术尚新且高度实验性，在实验室研究能够转化为大规模临床应用之前，仍有许多实际挑战必须克服。组织工程目前是医学研究中一个不断发展的领域；在本综述中，我们将讨论使用脂肪干细胞的组织工程应用中生物材料和支架的研究进展。
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