Muoth Carina, Aengenheister Leonie, Kucki Melanie, Wick Peter, Buerki-Thurnherr Tina
Empa-Swiss Federal Laboratories for Materials Science & Technology, St. Gallen, Switzerland.
Nanomedicine (Lond). 2016 Apr;11(8):941-57. doi: 10.2217/nnm-2015-0012. Epub 2016 Mar 16.
The human placenta is a multifunctional organ constituting the barrier between maternal and fetal tissues. Nanoparticles can cross the placental barrier, and there is increasing evidence that the extent of transfer is dependent on particle characteristics and functionalization. While translocated particles may pose risks to the growing fetus particles may also be engineered to enable new particle-based therapies in pregnancy. In both cases, a comprehensive understanding of nanoparticle uptake, accumulation and translocation is indispensable and requires predictive placental transfer models. We examine and evaluate the current literature to draw first conclusions on the possibility to steer translocation of nanoparticles. In addition, we discuss if current placental models are suitable for nanoparticle transfer studies and suggest strategies to improve their predictability.
人类胎盘是一个多功能器官，构成了母体组织与胎儿组织之间的屏障。纳米颗粒能够穿过胎盘屏障，并且越来越多的证据表明，转运程度取决于颗粒特性和功能化。虽然转运的颗粒可能会对发育中的胎儿构成风险，但颗粒也可以被设计用于实现妊娠期基于颗粒的新疗法。在这两种情况下，全面了解纳米颗粒的摄取、积累和转运是必不可少的，并且需要预测性的胎盘转运模型。我们研究和评估当前的文献，以得出关于控制纳米颗粒转运可能性的初步结论。此外，我们讨论当前的胎盘模型是否适用于纳米颗粒转运研究，并提出提高其预测性的策略。
