玫瑰茄（Hibiscus sabdariffa L.）对成年代谢综合征患者氧化应激及血脂、胰岛素和超敏C反应蛋白血清水平影响的评估：一项双盲安慰剂对照临床试验

Evaluation of the effects of roselle (Hibiscus sabdariffa L.) on oxidative stress and serum levels of lipids, insulin and hs-CRP in adult patients with metabolic syndrome: a double-blind placebo-controlled clinical trial.

作者信息

Asgary Sedigheh, Soltani Rasool, Zolghadr Mohsen, Keshvari Mahtab, Sarrafzadegan Nizal

出版信息

J Complement Integr Med. 2016 Jun 1;13(2):175-80. doi: 10.1515/jcim-2015-0030.

DOI:10.1515/jcim-2015-0030

PMID:26982618

Abstract

BACKGROUND

Roselle (Hibiscus sabdariffa L.) is a plant with antihyperlipidemic and antihypertensive effects. This study aimed to evaluate the effects of roselle calyces on the serum levels of lipids and insulin, inflammation, and oxidative stress in patients with metabolic syndrome (MetS).

METHODS

Forty adult patients with MetS were randomly assigned to receive either 500 mg of H. sabdariffa calyx powder or placebo once daily for 4 weeks. Systolic and diastolic blood pressures (SBP and DBP) and BMI (body mass index) as well as fasting serum levels of glucose (FPG; fasting plasma glucose), insulin, lipoproteins, triglycerides (TG), high-sensitivity C-reactive protein (hs-CRP), and malondialdehyde (MDA) were determined pre- and post-intervention and compared.

RESULTS

H. sabdariffa significantly reduced serum TG (p=0.044) and SBP (p=0.049) compared to placebo. All other variables were not significantly affected by the interventions.

CONCLUSIONS

Daily consumption of 500 mg of H. sabdariffa L. calyx powder can decrease SBP and serum TG in MetS patients.

摘要

背景

玫瑰茄（Hibiscus sabdariffa L.）是一种具有降血脂和降血压作用的植物。本研究旨在评估玫瑰茄花萼对代谢综合征（MetS）患者血脂、胰岛素水平、炎症及氧化应激的影响。

方法

40例成年MetS患者被随机分为两组，一组每天服用500毫克玫瑰茄花萼粉，另一组服用安慰剂，持续4周。在干预前后分别测定收缩压和舒张压（SBP和DBP）、体重指数（BMI）以及空腹血糖（FPG；空腹血浆葡萄糖）、胰岛素、脂蛋白、甘油三酯（TG）、高敏C反应蛋白（hs-CRP）和丙二醛（MDA）的血清水平，并进行比较。