Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, Reading, RG6 6AP, UK.
Department of Biochemistry, Bayero University, P.M.B. 3011, Kano, Nigeria.
Nutrients. 2019 Feb 5;11(2):341. doi: 10.3390/nu11020341.
BACKGROUND/OBJECTIVES: The acute impact of Hibiscus sabdariffa calyces (HSC) extract on postprandial vascular function and other cardiometabolic risk factors have not been studied previously. This study investigated the acute impact of HSC extract consumption on blood pressure (BP), vascular function and other cardiometabolic risk markers.
SUBJECTS/METHODS: Twenty-five men with 1% to 10% cardiovascular disease (CVD) risk (determined by QRISK2) were randomised to consume either 250 mL of the aqueous extract of HSC or water with breakfast in a randomised, controlled, single-blinded, 2-meal cross-over study (ClinicalTrials.gov, NTC02165553) with a two weeks washout period between study days. BP was measured at baseline and hourly for 4 h. Flow mediated dilatation (FMD) of the branchial artery was measured at baseline, 2 and 4 h post intervention drink consumption.
Acute consumption of aqueous extract of HSC caused a significant increase in % FMD ( < 0.001), a non-significant decrease in systolic BP (SBP) and diastolic BP (DBP); non-significant increase in urinary and plasma nitric oxide (NOx) and reduced response of serum glucose, plasma insulin, serum triacylglycerol and C-reactive protein (CRP) levels; significant ( = 0.026) improvement in the area under systemic antioxidant response curve (0 to 2 h); no significant changes in arterial stiffness following the acute consumption of the extract of HSC. Gallic acid, 4-O-methylgallic acid, 3-O-methylgallic acid and hippuric acid reached a maximum plasma concentration at 1 to 2 h post consumption of the extract of HSC.
The extract of HSC improved postprandial vascular function and may be a useful dietary strategy to reduce endothelial dysfunction and CVD risk, although this requires confirmation.
背景/目的：之前尚未研究过洛神花萼提取物（HSC）对餐后血管功能和其他心血管代谢危险因素的急性影响。本研究调查了 HSC 提取物摄入对血压（BP）、血管功能和其他心血管代谢风险标志物的急性影响。
受试者/方法：25 名心血管疾病（CVD）风险为 1%至 10%的男性（通过 QRISK2 确定）随机分为两组，分别在早餐时饮用 250 毫升 HSC 的水提物或水，采用随机、对照、单盲、2 餐交叉研究（ClinicalTrials.gov，NTC02165553），两次研究日之间有两周洗脱期。在基线和 4 小时内每小时测量血压。在基线、干预后 2 小时和 4 小时测量颈总动脉血流介导的扩张（FMD）。
HSC 水提物的急性摄入导致 %FMD 显著增加（<0.001），收缩压（SBP）和舒张压（DBP）略有下降；尿和血浆中一氧化氮（NOx）略有增加，血糖、胰岛素、三酰甘油和 C 反应蛋白（CRP）水平的反应性降低；全身抗氧化反应曲线下面积显著改善（0 至 2 小时；=0.026）；HSC 提取物摄入后动脉僵硬度无明显变化。在摄入 HSC 提取物后 1 至 2 小时，没食子酸、4-O-甲基没食子酸、3-O-甲基没食子酸和马尿酸达到血浆浓度峰值。
HSC 提取物改善了餐后血管功能，可能是减少内皮功能障碍和 CVD 风险的有用饮食策略，尽管这需要进一步证实。
