乙型和丙型肝炎病毒感染的体内模型。
In vivo models of hepatitis B and C virus infection.
作者信息
Winer Benjamin Y, Ding Qiang, Gaska Jenna M, Ploss Alexander
机构信息
Department of Molecular Biology, Princeton University, NJ, USA.
出版信息
FEBS Lett. 2016 Jul;590(13):1987-99. doi: 10.1002/1873-3468.12157. Epub 2016 Apr 8.
Abstract
Globally, more than 500 million individuals are chronically infected with hepatitis B (HBV), delta (HDV), and/or C (HCV) viruses, which can result in severe liver disease. Mechanistic studies of viral persistence and pathogenesis have been hampered by the scarcity of animal models. The limited species and cellular host range of HBV, HDV, and HCV, which robustly infect only humans and chimpanzees, have posed challenges for creating such animal models. In this review, we will discuss the barriers to interspecies transmission and the progress that has been made in our understanding of the HBV, HDV, and HCV life cycles. Additionally, we will highlight a variety of approaches that overcome these barriers and thus facilitate in vivo studies of these hepatotropic viruses.
摘要
在全球范围内，超过5亿人长期感染乙型肝炎病毒（HBV）、丁型肝炎病毒（HDV）和/或丙型肝炎病毒（HCV），这些病毒可导致严重的肝脏疾病。病毒持续存在和发病机制的研究因动物模型的稀缺而受到阻碍。HBV、HDV和HCV的宿主物种和细胞范围有限，仅能在人类和黑猩猩中有效感染，这给创建此类动物模型带来了挑战。在这篇综述中，我们将讨论种间传播的障碍以及我们在理解HBV、HDV和HCV生命周期方面取得的进展。此外，我们将重点介绍克服这些障碍从而促进对这些嗜肝病毒进行体内研究的各种方法。
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