Maisonneuve B G C, Honegger T, Cordeiro J, Lecarme O, Thiry T, Fuard D, Berton K, Picard E, Zelsmann M, Peyrade D
CEA , INAC-SiNAPS, F-38054 Grenoble, France.
Biomicrofluidics. 2016 Mar 3;10(2):024103. doi: 10.1063/1.4943124. eCollection 2016 Mar.
With the rise of microfluidics for the past decade, there has come an ever more pressing need for a low-cost and rapid prototyping technology, especially for research and education purposes. In this article, we report a rapid prototyping process of chromed masks for various microfluidic applications. The process takes place out of a clean room, uses a commercially available video-projector, and can be completed in less than half an hour. We quantify the ranges of fields of view and of resolutions accessible through this video-projection system and report the fabrication of critical microfluidic components (junctions, straight channels, and curved channels). To exemplify the process, three common devices are produced using this method: a droplet generation device, a gradient generation device, and a neuro-engineering oriented device. The neuro-engineering oriented device is a compartmentalized microfluidic chip, and therefore, required the production and the precise alignment of two different masks.
在过去十年中，随着微流控技术的兴起，对于低成本且快速成型技术的需求日益迫切，特别是用于研究和教育目的。在本文中，我们报告了用于各种微流控应用的镀铬掩膜的快速成型工艺。该工艺在洁净室外进行，使用市售的视频投影仪，并且可以在半小时内完成。我们量化了通过该视频投影系统可获得的视野范围和分辨率范围，并报告了关键微流控部件（交叉点、直通道和弯曲通道）的制造情况。为了举例说明该工艺，使用这种方法制造了三种常见设备：液滴生成设备、梯度生成设备和面向神经工程的设备。面向神经工程的设备是一种分隔式微流控芯片，因此，需要制作和精确对准两种不同的掩膜。
