Querques Giuseppe, Miere Alexandra, Souied Eric H
Dev Ophthalmol. 2016;56:57-61. doi: 10.1159/000442779. Epub 2016 Mar 15.
To characterize the imaging features of type 3 neovascularization secondary to exudative age-related macular degeneration on optical coherence tomography (OCT) angiography (OCTA).
Patients diagnosed with treatment-naïve early-stage type 3 neovascularization underwent multimodal imaging, including color retinal photography or multicolor imaging, fluorescein angiography, indocyanine green angiography, spectral-domain OCT and OCTA. The OCTA features of type 3 neovascularization were analyzed and correlated with the findings on angiography and spectral-domain OCT.
OCTA showed lesions characterized by a retinal-retinal anastomosis. These lesions emerged from the deep capillary plexus and formed a clear, tuft-shaped, high-flow network in the outer retinal segment in all eyes, abutting in the subretinal pigment epithelium space. In most cases, a small, clew-like lesion was present in the choriocapillaris segment. Moreover, in some cases, this clew-like lesion seemed to be connected to the choroid through a small-caliber vessel.
OCTA of treatment-naïve type 3 neovascularization shows high-flow, tuft-shaped, abnormal outer retinal proliferation that is almost consistently associated with a small, clew-like lesion in the choriocapillaris layer.
通过光学相干断层扫描血管造影（OCTA）对渗出性年龄相关性黄斑变性继发的3型新生血管形成的影像学特征进行表征。
对诊断为未经治疗的早期3型新生血管形成的患者进行多模态成像，包括彩色视网膜照相或多色成像、荧光素血管造影、吲哚菁绿血管造影、光谱域光学相干断层扫描（OCT）和OCTA。分析3型新生血管形成的OCTA特征，并将其与血管造影和光谱域OCT的结果相关联。
OCTA显示病变以视网膜-视网膜吻合为特征。这些病变起源于深层毛细血管丛，在所有眼中均在视网膜外段形成一个清晰的、簇状的高流量网络，邻近视网膜色素上皮下间隙。在大多数情况下，脉络膜毛细血管段存在一个小的、线团状病变。此外，在某些情况下，这个线团状病变似乎通过一条小口径血管与脉络膜相连。
未经治疗的3型新生血管形成的OCTA显示高流量、簇状、异常的视网膜外增殖，几乎总是与脉络膜毛细血管层中的一个小的、线团状病变相关。
