UCLA-Kern Medical, Bakersfield, CA, USA.
J Investig Med High Impact Case Rep. 2020 Jan-Dec;8:2324709620959880. doi: 10.1177/2324709620959880.
is a species that has received more recognition in the recent past as distinct from is known to cause meningeal disease in both immunocompetent and immunosuppressed hosts. Patients may be clinically asymptomatic until immunosuppressive conditions occur such as corticosteroid treatment or an HIV infection. HIV-associated cryptococcal infections are most often due to is found in a minority. Speciation and subtyping of are not always accomplished. In many parts of the world, there is no availability for speciation of . Travel history may provide a clue to the most probable species. This case demonstrates a case of meningitis with a multiplicity of complications. These include advanced HIV disease secondary to nonadherence, immune reconstitution inflammatory syndrome, and superior sagittal sinus thrombosis. The patient represented diagnostic and therapeutic dilemmas over time. Headache was the primary symptom in cryptococcal meningitis, immune reconstitution inflammatory syndrome, and superior sagittal sinus thrombosis. All are discussed in detail as potential etiologies for the primary disease. Isavuconazonium is a relatively new broad-spectrum antifungal azole that was used as salvage therapy.
是一种近年来被认为与不同的物种，已知可引起免疫功能正常和免疫抑制宿主的脑膜疾病。患者在发生免疫抑制等情况之前可能没有临床症状，如皮质类固醇治疗或 HIV 感染。与 HIV 相关的隐球菌感染大多是由于所致，而在少数情况下是由所致。并非总能完成的种系发生和亚型划分。在世界上许多地方，无法对进行种系发生鉴定。旅行史可能提供最可能的物种线索。本病例展示了一例伴有多种并发症的脑膜炎。这些并发症包括因不遵医嘱而导致的晚期 HIV 疾病、免疫重建炎症综合征和上矢状窦血栓形成。随着时间的推移，该患者表现出诊断和治疗上的困境。头痛是隐球菌性脑膜炎、免疫重建炎症综合征和上矢状窦血栓形成的主要症状。所有这些都作为原发性疾病的潜在病因进行了详细讨论。伊曲康唑是一种新型广谱抗真菌唑类药物，曾被用作挽救治疗。
