Hu Wei, Yang Cui, Guo Xiaodan, Wu Yihong, Loh Xian Jun, Li Zibiao, Wu Yun-Long, Wu Caisheng
Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.
School of Medicine, Xiamen University, Xiamen 361003, China.
Gels. 2022 Jul 6;8(7):423. doi: 10.3390/gels8070423.
Myocardial infarction (MI) has become one of the serious diseases threatening human life and health. However, traditional treatment methods for MI have some limitations, such as irreversible myocardial necrosis and cardiac dysfunction. Fortunately, recent endeavors have shown that hydrogel materials can effectively prevent negative remodeling of the heart and improve the heart function and long-term prognosis of patients with MI due to their good biocompatibility, mechanical properties, and electrical conductivity. Therefore, this review aims to summarize the research progress of injectable hydrogel in the treatment of MI in recent years and to introduce the rational design of injectable hydrogels in myocardial repair. Finally, the potential challenges and perspectives of injectable hydrogel in this field will be discussed, in order to provide theoretical guidance for the development of new and effective treatment strategies for MI.
心肌梗死（MI）已成为威胁人类生命健康的严重疾病之一。然而，传统的心肌梗死治疗方法存在一些局限性，如不可逆的心肌坏死和心脏功能障碍。幸运的是，最近的研究表明，水凝胶材料由于其良好的生物相容性、机械性能和导电性，能够有效预防心脏的负性重构，并改善心肌梗死患者的心脏功能和长期预后。因此，本综述旨在总结近年来可注射水凝胶在心肌梗死治疗中的研究进展，并介绍可注射水凝胶在心肌修复中的合理设计。最后，将讨论可注射水凝胶在该领域的潜在挑战和前景，以便为开发新的有效心肌梗死治疗策略提供理论指导。
