Pokharel Amrit, Shrestha Gauri Shankar, Shrestha Jyoti Baba
Department of Ophthalmology, Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal.
B P Koirala Lions Centre for Ophthalmic Studies, Institute of Medicine, Kathmandu, Nepal.
Clin Ophthalmol. 2016 Mar 21;10:511-9. doi: 10.2147/OPTH.S95956. eCollection 2016.
To record the normative values for macular thickness and macular volume in normal Nepalese eyes.
In all, 126 eyes of 63 emmetropic subjects (mean age: 21.17±6.76 years; range: 10-37 years) were assessed for macular thickness and macular volume, using spectral domain-optical coherence tomography over 6×6 mm(2) in the posterior pole. A fast macular thickness protocol was employed. Statistics such as the mean, median, standard deviation, percentiles, and range were used, while a P-value was set at 0.05 to test significance.
Average macular thickness and total macular volume were larger in males compared to females. With each year of increasing age, these variables decreased by 0.556 μm and 0.0156 mm(3) for average macular thickness and total macular volume, respectively. The macular thickness was greatest in the inner superior section and lowest at the center of the fovea. The volume was greatest in the outer nasal section and thinnest in the fovea. The central subfield thickness (r=-0.243, P=0.055) and foveal volume (r=0.216, P=0.09) did not correlate with age.
Males and females differ significantly with regard to macular thickness and macular volume measurements. Reports by other studies that the increase in axial length reduced thickness and volume, were negated by this study which found a positive correlation among axial length, thickness, and volume.
记录正常尼泊尔人眼睛黄斑厚度和黄斑体积的正常值。
使用光谱域光学相干断层扫描技术，对63名正视眼受试者（平均年龄：21.17±6.76岁；范围：10 - 37岁）的126只眼睛进行后极部6×6 mm²区域的黄斑厚度和黄斑体积评估。采用快速黄斑厚度测量方案。使用均值、中位数、标准差、百分位数和范围等统计数据，设定P值为0.05以检验显著性。
男性的平均黄斑厚度和总黄斑体积大于女性。随着年龄每增加一岁，平均黄斑厚度和总黄斑体积分别减少0.556μm和0.0156mm³。黄斑厚度在内上象限最大，在中央凹中心最低。黄斑体积在外鼻象限最大，在中央凹最薄。中央子区域厚度（r = -0.243，P = 0.055）和中央凹体积（r = 0.216，P = 0.09）与年龄无相关性。
男性和女性在黄斑厚度和黄斑体积测量方面存在显著差异。其他研究报告称眼轴长度增加会降低厚度和体积，但本研究否定了这一观点，本研究发现眼轴长度、厚度和体积之间呈正相关。
