Song Ai-Ping, Wu Xin-Yi, Wang Jian-Rong, Liu Wei, Sun Yan, Yu Tao
Department of Ophthalmology, Qilu Hospital Affiliated Shandong University, Jinan 250012, Shandong Province, China ; Department of Ophthalmology, Second People's Hospital, Jinan 250001, Shandong Province, China.
Department of Ophthalmology, Qilu Hospital Affiliated Shandong University, Jinan 250012, Shandong Province, China.
Int J Ophthalmol. 2014 Feb 18;7(1):122-7. doi: 10.3980/j.issn.2222-3959.2014.01.23. eCollection 2014.
To investigate the changes of retinal thickness in macula of high myopic eyes using spectral domain optical coherence tomography (OCT).
Middle-aged and young myopic patients were divided into three groups according to their refractive error/axial length: low and medium myopia group (LMMG), high myopia group (HMG) and super high myopia group (SHMG). Cirrus HD-OCT was used to evaluate total average macular thickness, central subfield thickness, inner/outer macular thickness and macular volume. The differences among experimental groups were analyzed by one-factor analysis of variance. Associations between macular thickness and refractive error/axial length were analyzed by Pearson correlation analysis.
There was no significant difference in age among the three groups (P=0.2789). The mean refraction error in the LMMG, HMG, and SHMG groups was -2.49±1.38D, -8.53±1.95D and -13.88±1.76D, respectively (P<0.001). The central subfield thickness of three groups was 244.56±12.19µm, 254.33±11.61µm and 261.75±11.83µm, respectively, and there were statistically significance between random two groups. The total average macular thickness, inner/outer macular thickness, and macular volume decreased with increased myopia/axial length. Average foveal thickness had negative correlations with refractive error (P<0.001), and positive correlations with axial length. The inferior and temporal inner macular thickness, all the quadrants of outer ring, total average macular thickness and macular volume featured positive correlations with refractive error, and negative correlations with axial length. Average foveal thickness, superior and temporal inner macular thicknesses, and temporal outer macular thickness was lower in females compared to males.
With an increase in myopia degree/axial length, the average foveal thickness increased and the inner/outer macular thickness decreased. Females featured thicker average foveal thickness, and thinner macular thickness compared to males.
采用谱域光学相干断层扫描（OCT）研究高度近视眼黄斑区视网膜厚度的变化。
将中青年近视患者按屈光不正/眼轴长度分为三组：中低度近视组（LMMG）、高度近视组（HMG）和超高度近视组（SHMG）。采用Cirrus HD-OCT评估黄斑区总平均厚度、中心子区域厚度、黄斑内外层厚度及黄斑体积。采用单因素方差分析分析各实验组之间的差异。采用Pearson相关分析分析黄斑厚度与屈光不正/眼轴长度之间的相关性。
三组患者年龄差异无统计学意义（P = 0.2789）。LMMG组、HMG组和SHMG组的平均屈光不正分别为-2.49±1.38D、-8.53±1.95D和-13.88±1.76D（P<0.001）。三组的中心子区域厚度分别为244.56±12.19μm、254.33±11.61μm和261.75±11.83μm，任意两组之间差异均有统计学意义。黄斑区总平均厚度、黄斑内外层厚度及黄斑体积随近视程度/眼轴长度增加而降低。平均黄斑中心凹厚度与屈光不正呈负相关（P<0.001），与眼轴长度呈正相关。黄斑内层下象限和颞侧厚度、外环所有象限、黄斑区总平均厚度及黄斑体积与屈光不正呈正相关，与眼轴长度呈负相关。女性的平均黄斑中心凹厚度、黄斑内层上象限和颞侧厚度以及黄斑外层颞侧厚度低于男性。
随着近视度数/眼轴长度增加，平均黄斑中心凹厚度增加，黄斑内外层厚度降低。女性的平均黄斑中心凹厚度较厚，黄斑厚度较薄。
