New England Eye Center, Tufts Medical Center, Boston, Massachusetts 02111, USA.
Retina. 2010 Feb;30(2):235-45. doi: 10.1097/IAE.0b013e3181bd2c3b.
The purpose of this study was to report normal macular thickness measurements and assess reproducibility of retinal thickness measurements acquired by a time-domain optical coherence tomography (OCT) (Stratus, Carl Zeiss Meditec, Inc., Dublin, CA) and three commercially available spectral/Fourier domain OCT instruments (Cirrus HD-OCT, Carl Zeiss Meditec, Inc.; RTVue-100, Optovue, Inc., Fremont, CA; 3D OCT-1000, Topcon, Inc., Paramus, NJ).
Forty randomly selected eyes of 40 normal, healthy volunteers were imaged. Subjects were scanned twice during 1 visit and a subset of 25 was scanned again within 8 weeks. Retinal thickness measurements were automatically generated by OCT software and recorded after manual correction. Regression and Bland-Altman plots were used to compare agreement between instruments. Reproducibility was analyzed by using intraclass correlation coefficients, and incidence of artifacts was determined.
Macular thickness measurements were found to have high reproducibility across all instruments with intraclass correlation coefficients values ranging 84.8% to 94.9% for Stratus OCT, 92.6% to 97.3% for Cirrus Cube, 76.4% to 93.7% for RTVue MM5, 61.1% to 96.8% for MM6, 93.1% to 97.9% for 3D OCT-1000 radial, and 31.5% to 97.5% for 3D macular scans. Incidence of artifacts was higher in spectral/Fourier domain instruments, ranging from 28.75% to 53.16%, compared with 17.46% in Stratus OCT. No significant age or sex trends were found in the measurements.
Commercial spectral/Fourier domain OCT instruments provide higher speed and axial resolution than the Stratus OCT, although they vary greatly in scanning protocols and are currently limited in their analysis functions. Further development of segmentation algorithms and quantitative features are needed to assist clinicians in objective use of these newer instruments to manage diseases.
本研究旨在报告正常黄斑厚度测量值，并评估通过时域光相干断层扫描（OCT）（Stratus，Carl Zeiss Meditec，Inc.，Dublin，CA）和三种市售的谱域/傅里叶域 OCT 仪器（Cirrus HD-OCT，Carl Zeiss Meditec，Inc.；RTVue-100，Optovue，Inc.，Fremont，CA；3D OCT-1000，Topcon，Inc.，Paramus，NJ）获得的视网膜厚度测量值的可重复性。
对 40 名随机选择的正常健康志愿者的 40 只眼进行成像。受检者在 1 次就诊期间接受了 2 次扫描，其中 25 名受检者在 8 周内再次接受了扫描。OCT 软件自动生成视网膜厚度测量值，并在手动校正后记录。使用回归和 Bland-Altman 图比较仪器之间的一致性。使用组内相关系数分析重复性，并确定伪影的发生率。
所有仪器的黄斑厚度测量值均具有较高的可重复性，Stratus OCT 的组内相关系数值范围为 84.8%至 94.9%，Cirrus Cube 的组内相关系数值范围为 92.6%至 97.3%，RTVue MM5 的组内相关系数值范围为 76.4%至 93.7%，MM6 的组内相关系数值范围为 61.1%至 96.8%，3D OCT-1000 径向的组内相关系数值范围为 93.1%至 97.9%，3D 黄斑扫描的组内相关系数值范围为 31.5%至 97.5%。与 Stratus OCT 的 17.46%相比，谱域/傅里叶域仪器的伪影发生率较高，范围为 28.75%至 53.16%。
商用谱域/傅里叶域 OCT 仪器的速度和轴向分辨率高于 Stratus OCT，但它们在扫描方案上差异很大，目前在分析功能上受到限制。需要进一步开发分割算法和定量特征，以帮助临床医生客观地使用这些新型仪器来治疗疾病。
