Koskinen Jyri-Pekka, Kiviranta Hannu, Vartiainen Erkki, Jousilahti Pekka, Vlasoff Tiina, von Hertzen Leena, Mäkelä Mika, Laatikainen Tiina, Haahtela Tari
Department of Allergy, Skin and Allergy Hospital, Helsinki University Hospital, Jatasalmentie 14a, 00830 Helsinki, Finland.
Department of Health Protection, National Institute for Health and Welfare, Kuopio, Finland.
Clin Transl Allergy. 2016 Apr 4;6:14. doi: 10.1186/s13601-016-0103-1. eCollection 2016.
Atopic allergy is much more common in Finnish compared with Russian Karelia, although these areas are geographically and genetically close. To explore the role of environmental chemicals on the atopy difference a random sample of 200 individuals, 25 atopic and 25 non-atopic school-aged children and their mothers, were studied. Atopy was defined as having at least one positive skin prick test response to 14 common inhalant and food allergens tested. Concentrations of 11 common environmental pollutants were measured in blood samples.
Overall, the chemical levels were much higher in Russia than in Finland, except for 2,2',4,4'-tetra-bromodiphenyl ether (BDE47). In Finland but not in Russia, the atopic children had higher concentrations of polychlorinated biphenyls and 1,1-Dichloro-2,2-bis-(p-chlorophenyl)-ethylene (DDE) than the non-atopic children. In Russia but not in Finland, the atopic mothers had higher DDE concentrations than the non-atopic mothers.
Higher concentrations of common environmental chemicals were measured in Russian compared with Finnish Karelian children and mothers. The chemicals did not explain the higher prevalence of atopy on the Finnish side.
尽管芬兰和俄罗斯卡累利阿地区在地理和基因上相近，但特应性过敏在芬兰比在俄罗斯卡累利阿更为常见。为了探究环境化学物质在特应性差异中的作用，我们对200名个体进行了随机抽样研究，其中包括25名患特应性疾病的学龄儿童、25名非特应性学龄儿童及其母亲。特应性被定义为对14种常见吸入性和食物过敏原进行皮肤点刺试验时至少有一次阳性反应。我们测量了血液样本中11种常见环境污染物的浓度。
总体而言，除2,2',4,4'-四溴二苯醚（BDE47）外，俄罗斯的化学物质水平比芬兰高得多。在芬兰，患特应性疾病的儿童体内多氯联苯和1,1-二氯-2,2-双（对氯苯基）乙烯（DDE）的浓度高于非特应性儿童，而在俄罗斯则不然。在俄罗斯，患特应性疾病的母亲体内DDE浓度高于非特应性母亲，而在芬兰则不然。
与芬兰卡累利阿的儿童和母亲相比，俄罗斯儿童和母亲体内常见环境化学物质的浓度更高。这些化学物质并不能解释芬兰特应性疾病患病率较高的原因。
