Muzalevskaya E N, Nikolaevskii V A, Chernov Yu N
Eksp Klin Farmakol. 2015;78(12):34-5.
An original technique has been developed for the biomicroscopy of small-intestine mesentery blood vessels in rats. Using this method, specific features of mic- rocirculatory process disturbances caused by isoniazid in high doses have been elucidated for the first time. It is established that intragastric introduction of iso- niazid (single daily dose of 542 mg/kg for 6 days) leads to pronounced disturbances of the microcirculatory process, accompanied by intravascular aggregation of erythrocytes, stasis, destructive changes in vessel walls, diapedesis, and hemorrhage over an area of (1.9-9.9) x 10⁻³ mm².
已开发出一种用于大鼠小肠系膜血管生物显微镜检查的原创技术。使用该方法，首次阐明了高剂量异烟肼引起的微循环过程紊乱的具体特征。已确定，胃内引入异烟肼（每日单次剂量542 mg/kg，持续6天）会导致微循环过程明显紊乱，伴有红细胞血管内聚集、血流淤滞、血管壁破坏变化、血细胞渗出以及面积为(1.9 - 9.9)×10⁻³ mm²的出血。
