Wu-chao Wu, Yafei Wu, Lei Zhao
Hua Xi Kou Qiang Yi Xue Za Zhi. 2015 Dec;33(6):651-5. doi: 10.7518/hxkq.2015.06.021.
Substantial evidence supports the relationship between chronic inflammation and cancer development. Numerous studies suggest that chronic inflammatory disease, such as periodontitis, contributes to head and neck squamous cell carcinoma development. Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the oral and maxillofacial regions. Porphyromonas gingivalis, one of the most important pathogens in association with periodontal disease, might have a potential correlation with OSCC. Along with the development of molecular biological techniques, the association between Porphyromonas gingivalis and OSCC has been greatly emphasized in recent years. This review summarizes the association between these variables and the potential mechanisms involved in such relationship.
大量证据支持慢性炎症与癌症发展之间的关系。众多研究表明，慢性炎症性疾病，如牙周炎，会促进头颈部鳞状细胞癌的发展。口腔鳞状细胞癌（OSCC）是口腔颌面部最常见的恶性肿瘤。牙龈卟啉单胞菌是与牙周疾病相关的最重要病原体之一，可能与OSCC存在潜在关联。随着分子生物学技术的发展，近年来牙龈卟啉单胞菌与OSCC之间的关联得到了极大的重视。本综述总结了这些变量之间的关联以及这种关系中涉及的潜在机制。
