口服活性炭对奎宁消除的影响。
Effect of oral activated charcoal on quinine elimination.
作者信息
Lockey D, Bateman D N
机构信息
Wolfson Unit of Clinical Pharmacology, The University, Newcastle upon Tyne.
出版信息
Br J Clin Pharmacol. 1989 Jan;27(1):92-4. doi: 10.1111/j.1365-2125.1989.tb05340.x.
Abstract
The effect of repeated dose oral activated charcoal on quinine elimination has been studied following a therapeutic (600 mg) dose of quinine bisulphate to seven normal volunteers. Activated charcoal lowered quinine half-life from 8.23 +/- 0.57 s.d. h to 4.55 +/- 0.15 s.d. h (P less than 0.001) and increased its oral clearance by 56%. Activated charcoal may have a role in the management of quinine poisoning.
摘要
对7名正常志愿者给予治疗剂量（600毫克）的硫酸奎宁后，研究了重复剂量口服活性炭对奎宁消除的影响。活性炭使奎宁半衰期从8.23±0.57标准差小时降至4.55±0.15标准差小时（P<0.001），并使其口服清除率提高了56%。活性炭可能在奎宁中毒的处理中发挥作用。
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