Zhang Yu-Dang, Shen Chun-Mei, Meng Hao-Tian, Guo Yu-Xin, Dong Qian, Yang Guang, Yan Jiang-Wei, Liu Yao-Shun, Mei Ting, Huang Rui-Zhe, Zhu Bo-Feng
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.
Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, P. R. China.
Electrophoresis. 2016 Jul;37(12):1669-75. doi: 10.1002/elps.201500425. Epub 2016 May 25.
X-chromosomal short tandem repeats (X-STRs) have been proved to be useful for some deficiency paternity cases in recent years. Here, we studied the genetic polymorphisms of 19 X-STR loci (DXS10148-DXS10135-DXS8378, DXS10159-DXS10162-DXS10164, DXS7132-DXS10079-DXS10074-DXS10075, DXS6809-DXS6789, DXS7424-DXS101, DXS10103-HPRTB-DXS10101 and DXS7423-DXS10134) in 252 male and 222 female individuals from Guanzhong Han population, China. No deviation for all 19 loci was observed from the Hardy-Weinberg equilibrium. The polymorphism information content values of the panel of 19 loci were more than 0.5 with the exception of the locus DXS7423. The combined power of discrimination were 0.9999999999999999999994340 in females and 0.9999999999997662 in males, respectively; and the combined mean exclusion chances were 0.999999993764 in duos and 0.999999999997444 in trios, respectively. The haplotype diversities for all the seven clusters of linked loci were more than 0.9. The results showed that the panel of 19 X-STR loci were powerful for forensic applications in Guanzhong Han population. Locus by locus population comparisons showed significant differences at more than seven loci between Guanzhong Han population and the groups from North America, Europe and Africa.
近年来，X染色体短串联重复序列（X-STRs）已被证明在一些父系缺失的亲子鉴定案例中很有用。在此，我们研究了中国关中汉族人群中252名男性和222名女性个体的19个X-STR基因座（DXS10148-DXS10135-DXS8378、DXS10159-DXS10162-DXS10164、DXS7132-DXS10079-DXS10074-DXS10075、DXS6809-DXS6789、DXS7424-DXS101、DXS10103-HPRTB-DXS10101以及DXS7423-DXS10134）的遗传多态性。所有19个基因座均未观察到偏离哈迪-温伯格平衡的情况。除DXS7423基因座外，19个基因座组合的多态性信息含量值均大于0.5。女性和男性的联合鉴别力分别为0.9999999999999999999994340和0.9999999999997662；双人组合和三人组合的联合平均排除率分别为0.999999993764和0.999999999997444。所有七个连锁基因座簇的单倍型多样性均大于0.9。结果表明，19个X-STR基因座组合在关中汉族人群的法医鉴定应用中具有强大作用。逐个基因座的群体比较显示，关中汉族人群与北美、欧洲和非洲群体之间在七个以上基因座存在显著差异。
