Blanken R, van Vilsteren M J, Tupker R A, Coenraads P J
Occupational Dermatology Unit, University Hospital Groningen, The Netherlands.
Contact Dermatitis. 1989 Feb;20(2):93-7. doi: 10.1111/j.1600-0536.1989.tb03114.x.
This study evaluates the influence of mineral oil and linoleic-acid-containing emulsions on the skin vapour loss (SVL) of detergent-induced irritant skin reactions. During a period of 2 weeks, 2 x 45 min applications of a sodium lauryl sulphate solution of low molarity were performed on the forearm of 9 volunteers. In the same period, a standard amount of each emulsion was applied on the induced irritant skin reactions, 3 times each day. The effect of the emulsions on the barrier function of the skin was evaluated by means of SVL measurements. The emulsion based on mineral greases significantly reduced SVL values during both weeks, possibly because of an occlusive effect. The emulsion with 15% of linoleic acid significantly reduced SVL values during the 1st week but not during the 2nd week. The emulsion with 38% of linoleic acid did not reduce SVL values at all.
本研究评估了矿物油和含亚油酸乳液对洗涤剂诱导的刺激性皮肤反应的皮肤水分流失（SVL）的影响。在2周的时间里，对9名志愿者的前臂进行了2次、每次45分钟的低摩尔浓度月桂醇硫酸酯钠溶液涂抹。在同一时期，将标准量的每种乳液涂抹在诱导的刺激性皮肤反应上，每天3次。通过测量皮肤水分流失来评估乳液对皮肤屏障功能的影响。基于矿物油脂的乳液在两周内均显著降低了皮肤水分流失值，这可能是由于其封闭作用。含15%亚油酸的乳液在第1周显著降低了皮肤水分流失值，但在第2周没有。含38%亚油酸的乳液根本没有降低皮肤水分流失值。
