Roalf David R, Moore Tyler M, Wolk David A, Arnold Steven E, Mechanic-Hamilton Dawn, Rick Jacqueline, Kabadi Sushila, Ruparel Kosha, Chen-Plotkin Alice S, Chahine Lama M, Dahodwala Nabila A, Duda John E, Weintraub Daniel A, Moberg Paul J
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
J Neurol Neurosurg Psychiatry. 2016 Dec;87(12):1303-1310. doi: 10.1136/jnnp-2015-312723. Epub 2016 Apr 12.
Screening for cognitive deficits is essential in neurodegenerative disease. Screening tests, such as the Montreal Cognitive Assessment (MoCA), are easily administered, correlate with neuropsychological performance and demonstrate diagnostic utility. Yet, administration time is too long for many clinical settings.
Item response theory and computerised adaptive testing simulation were employed to establish an abbreviated MoCA in 1850 well-characterised community-dwelling individuals with and without neurodegenerative disease.
8 MoCA items with high item discrimination and appropriate difficulty were identified for use in a short form (s-MoCA). The s-MoCA was highly correlated with the original MoCA, showed robust diagnostic classification and cross-validation procedures substantiated these items.
Early detection of cognitive impairment is an important clinical and public health concern, but administration of screening measures is limited by time constraints in demanding clinical settings. Here, we provide as-MoCA that is valid across neurological disorders and can be administered in approximately 5 min.
认知缺陷筛查在神经退行性疾病中至关重要。筛查测试，如蒙特利尔认知评估量表（MoCA），易于实施，与神经心理表现相关且具有诊断效用。然而，在许多临床环境中，其施测时间过长。
采用项目反应理论和计算机自适应测试模拟，在1850名有或无神经退行性疾病的、特征明确的社区居民中建立简版MoCA。
识别出8个具有高项目区分度和适当难度的MoCA项目用于简版（s-MoCA）。s-MoCA与原始MoCA高度相关，显示出强大的诊断分类能力，交叉验证程序证实了这些项目。
认知障碍的早期检测是重要的临床和公共卫生问题，但在要求较高的临床环境中，筛查措施的实施受到时间限制。在此，我们提供了一种在各种神经系统疾病中均有效的s-MoCA，且施测时间约为5分钟。
