致癌潜能数据库中492种啮齿动物致癌物的致癌效力和阳性总结。
Summary of carcinogenic potency and positivity for 492 rodent carcinogens in the carcinogenic potency database.
作者信息
Gold L S, Slone T H, Bernstein L
机构信息
Biology and Medicine Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720.
出版信息
Environ Health Perspect. 1989 Feb;79:259-72. doi: 10.1289/ehp.8979259.
Abstract
A tabulation of carcinogenic potency (TD50) by species for 492 chemicals that induce tumors in rats or mice is presented. With the use of the Carcinogenic Potency Database, experimental results are summarized by indicating in which sex-species groups the chemical was tested and the respective evaluations of carcinogenicity. A comparison of three summary measures of TD50 for chemicals with more than one positive experiment per species shows that the most potent TD50 value is similar to measures that average values or functions of values. This tabulation can be used to investigate associations between rodent potency and other factors such as mutagenicity, teratogenicity, chemical structure, and human exposure.
摘要
列出了492种在大鼠或小鼠中诱发肿瘤的化学物质按物种划分的致癌效力（半数致癌剂量，TD50）。利用致癌效力数据库，通过指出化学物质所测试的性别-物种组以及相应的致癌性评估来总结实验结果。对每个物种有多个阳性实验的化学物质的TD50的三种汇总测量方法进行比较，结果表明最有效的TD50值类似于对值进行平均或函数处理的测量方法。该列表可用于研究啮齿动物效力与其他因素（如诱变性、致畸性、化学结构和人类接触）之间的关联。
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