327项化学致癌性研究的比较结果。
Comparative results of 327 chemical carcinogenicity studies.
作者信息
Haseman J K, Huff J E, Zeiger E, McConnell E E
机构信息
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
出版信息
Environ Health Perspect. 1987 Oct;74:229-35. doi: 10.1289/ehp.8774229.
Abstract
The National Cancer Institute (NCI) and the National Toxicology Program (NTP) have carried out a number of laboratory animal carcinogenicity studies and presented the results of these experiments in a series of Technical Reports. This paper tabulates the results of the 327 NCI/NTP studies carried out to date on 308 distinct chemicals, and discusses certain issues relevant to the evaluation of carcinogenicity in these experiments. This compilation of results from NCI/NTP carcinogenicity experiments provides a large database that can be used to study structure-activity correlations, interspecies concordance, and associations between laboratory animal carcinogenicity and other toxicological effects.
摘要
美国国立癌症研究所（NCI）和国家毒理学计划（NTP）开展了多项实验动物致癌性研究，并在一系列技术报告中公布了这些实验的结果。本文将迄今为止针对308种不同化学品开展的327项NCI/NTP研究的结果制成表格，并讨论了这些实验中与致癌性评估相关的某些问题。这份来自NCI/NTP致癌性实验的结果汇编提供了一个庞大的数据库，可用于研究构效关系、种间一致性以及实验动物致癌性与其他毒理学效应之间的关联。
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