Garza-Mayers Anna Cristina, McClurkin Michael, Smith Gideon P
Harvard Medical School, Boston, Massachusetts.
Massachusetts General Hospital, Department of Dermatology, Boston, Massachusetts.
Dermatol Ther. 2016 Jul;29(4):274-83. doi: 10.1111/dth.12358. Epub 2016 Apr 12.
Discoid lupus erythematosus (DLE) is a chronic cutaneous disease characterized by inflammatory plaques that, in the absence of prompt diagnosis and treatment, may lead to disfiguring scarring and skin atrophy. However, there is limited evidence for which treatments are most effective. Currently, no medications have been approved specifically for the treatment of DLE. Many of the drugs described in the literature were developed for use in other immune disorders. This review will summarize current therapeutic options for DLE and their supporting evidence with discussion of prevention, topical measures, physical modalities, and systemic therapies, including newer potential therapies.
盘状红斑狼疮（DLE）是一种慢性皮肤病，其特征为炎症性斑块，若未得到及时诊断和治疗，可能会导致毁容性瘢痕和皮肤萎缩。然而，关于哪些治疗方法最有效的证据有限。目前，尚无专门获批用于治疗DLE的药物。文献中描述的许多药物是为其他免疫疾病开发的。本综述将总结DLE目前的治疗选择及其支持证据，并讨论预防、局部措施、物理治疗方法和全身治疗，包括新的潜在治疗方法。
