Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232.
Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232; Department of Medicine, Division of Hematology and Oncology, Vanderbilt University School of Medicine, Nashville, TN, 37232.
Transl Oncol. 2016 Apr;9(2):163-165. doi: 10.1016/j.tranon.2016.03.001.
This perspective describes the motivation, development, and implementation of pathway-based content for My Cancer Genome, an online precision medicine knowledge resource describing clinical implications of genetic alterations in cancer. As researchers uncover more about cancer pathogenesis, we are learning more not only about the specific genes and proteins involved but also about how those genes and proteins interact with others along cell signaling pathways. This knowledge has led researchers and clinicians to begin to think about cancer therapy using a pathway-based approach. To facilitate this approach, My Cancer Genome used a list of more than 800 cancer-related genes to identify 20 cancer-relevant pathways and then created content focused on demonstrating the therapeutic relevance of these pathways.
本文档描述了基于途径的内容的动机、开发和实施，该内容是在线精准医学知识库 My Cancer Genome 的一部分，用于描述癌症中遗传改变的临床意义。随着研究人员对癌症发病机制的了解不断深入，我们不仅了解了涉及的特定基因和蛋白质，还了解了这些基因和蛋白质如何沿着细胞信号通路与其他基因和蛋白质相互作用。这一知识促使研究人员和临床医生开始考虑采用基于途径的方法进行癌症治疗。为了促进这种方法，My Cancer Genome 使用了一份包含 800 多个与癌症相关的基因的列表，以确定 20 条与癌症相关的途径，然后创建了专注于展示这些途径治疗相关性的内容。
