Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.
Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, 65 Landsdowne Street, Rm. 265, Cambridge, MA, 02139, USA.
Appl Microbiol Biotechnol. 2016 Jun;100(11):4723-34. doi: 10.1007/s00253-016-7495-7. Epub 2016 Apr 15.
Helicobacter pylori is responsible for worldwide chronic bacterial infection in humans affecting approximately half of the world's population. H. pylori is associated with significant morbidity and mortality including gastric cancer. The infection has both direct and indirect impacts on economic and overall well-being of patients; hence, there is a great need for diagnostic markers that could be used in the development of diagnostic kits. Here, we briefly review general aspects of H. pylori infection and the diagnostic biomarkers used in laboratory tests today with a focus on the potential role of microfluidic systems in future immunodiagnosis platforms.
幽门螺杆菌是全球范围内导致人类慢性细菌感染的元凶，影响着全球约一半的人口。幽门螺杆菌与重大发病率和死亡率相关，包括胃癌。该感染对患者的经济和整体健康状况有着直接和间接的影响；因此，非常需要能够用于开发诊断试剂盒的诊断标志物。在这里，我们简要回顾了幽门螺杆菌感染的一般方面和当今实验室检测中使用的诊断生物标志物，并重点介绍了微流控系统在未来免疫诊断平台中的潜在作用。
