胃癌中胃微生物群和代谢物的改变：最新综述
Alterations in the gastric microbiota and metabolites in gastric cancer: An update review.
作者信息
Lei Changzhen, Gong Daojun, Zhuang Bo, Zhang Zhiwei
机构信息
Department of Gastrointestinal Surgery, Jinhua Hospital of Zhejiang University, Jinhua, China.
出版信息
Front Oncol. 2022 Aug 23;12:960281. doi: 10.3389/fonc.2022.960281. eCollection 2022.
Abstract
Gastric cancer (GC) is one of the leading causes of cancer mortality worldwide. Numerous studies have shown that the gastric microbiota can contribute to the occurrence and development of GC by generating harmful microbial metabolites, suggesting the possibility of discovering biomarkers. Metabolomics has emerged as an advanced promising analytical method for the analysis of microbiota-derived metabolites, which have greatly accelerated our understanding of host-microbiota metabolic interactions in GC. In this review, we briefly compiled recent research progress on the changes of gastric microbiota and its metabolites associated with GC. And we further explored the application of metabolomics and gastric microbiome association analysis in the diagnosis, prevention and treatment of GC.
摘要
胃癌（GC）是全球癌症死亡的主要原因之一。众多研究表明，胃微生物群可通过产生有害的微生物代谢产物促进胃癌的发生和发展，这提示了发现生物标志物的可能性。代谢组学已成为一种先进且有前景的分析方法，用于分析微生物群衍生的代谢产物，极大地加速了我们对胃癌中宿主-微生物群代谢相互作用的理解。在本综述中，我们简要汇总了与胃癌相关的胃微生物群及其代谢产物变化的近期研究进展。并且我们进一步探讨了代谢组学与胃微生物组关联分析在胃癌诊断、预防和治疗中的应用。
相似文献
1
Alterations in the gastric microbiota and metabolites in gastric cancer: An update review.胃癌中胃微生物群和代谢物的改变：最新综述
Front Oncol. 2022 Aug 23;12:960281. doi: 10.3389/fonc.2022.960281. eCollection 2022.
2
Alterations in the Gut Microbiota and Their Metabolites in Colorectal Cancer: Recent Progress and Future Prospects.结直肠癌中肠道微生物群及其代谢产物的改变：最新进展与未来展望
Front Oncol. 2022 Feb 11;12:841552. doi: 10.3389/fonc.2022.841552. eCollection 2022.
3
The role of microbiota in gastric cancer: A comprehensive review.肠道菌群在胃癌中的作用：一篇全面的综述。
Helicobacter. 2024 Mar-Apr;29(2):e13071. doi: 10.1111/hel.13071.
4
Microbial Metabolites in Colorectal Cancer: Basic and Clinical Implications.结直肠癌中的微生物代谢产物：基础与临床意义
Metabolites. 2021 Mar 10;11(3):159. doi: 10.3390/metabo11030159.
5
Metabolomics of Gastric Cancer.胃癌的代谢组学。
Adv Exp Med Biol. 2021;1280:291-301. doi: 10.1007/978-3-030-51652-9_20.
6
Metabolomics-Microbiome Crosstalk in the Breast Cancer Microenvironment.乳腺癌微环境中的代谢组学与微生物组相互作用
Metabolites. 2021 Nov 4;11(11):758. doi: 10.3390/metabo11110758.
7
Metabolome analysis for investigating host-gut microbiota interactions.代谢组学分析研究宿主-肠道微生物群相互作用。
J Formos Med Assoc. 2019 Mar;118 Suppl 1:S10-S22. doi: 10.1016/j.jfma.2018.09.007. Epub 2018 Sep 27.
9
The Association Between the Gut Microbiome, Nutritional Habits, Antibiotics, and Gastric Cancer: a Scoping Review.肠道微生物群、营养习惯、抗生素与胃癌之间的关联：一项范围综述
Curr Nutr Rep. 2022 Mar;11(1):19-38. doi: 10.1007/s13668-021-00391-z. Epub 2022 Jan 12.
10
Role of the Gastric Microbiome in Gastric Cancer: From Carcinogenesis to Treatment.胃微生物群在胃癌中的作用：从致癌作用到治疗
Front Microbiol. 2021 Mar 15;12:641322. doi: 10.3389/fmicb.2021.641322. eCollection 2021.
引用本文的文献
1
Gastric Cancer and Microbiota: Exploring the Microbiome's Role in Carcinogenesis and Treatment Strategies.胃癌与微生物群：探索微生物组在致癌作用及治疗策略中的作用
Life (Basel). 2025 Jun 23;15(7):999. doi: 10.3390/life15070999.
2
Unveiling gastric precancerous stages: metabolomic insights for early detection and intervention.揭示胃癌前阶段：早期检测和干预的代谢组学见解
BMC Gastroenterol. 2025 Apr 29;25(1):318. doi: 10.1186/s12876-025-03898-9.
3
Molecular Alterations in Gastric Intestinal Metaplasia Shed Light on Alteration of Methionine Metabolism: Insight into New Diagnostic and Treatment Approaches.胃黏膜肠化生中的分子改变揭示蛋氨酸代谢变化：对新诊断和治疗方法的见解
Biomedicines. 2025 Apr 15;13(4):964. doi: 10.3390/biomedicines13040964.
4
Analysis of metabolic characteristics of metabolic syndrome in elderly patients with gastric cancer by non-targeted metabolomics.基于非靶向代谢组学分析老年胃癌患者代谢综合征的代谢特征
World J Gastrointest Oncol. 2024 Jun 15;16(6):2419-2428. doi: 10.4251/wjgo.v16.i6.2419.
5
Bioinformatics Analysis and Validation of Potential Markers Associated with Prediction and Prognosis of Gastric Cancer.生物信息学分析和验证与胃癌预测和预后相关的潜在标志物。
Int J Mol Sci. 2024 May 28;25(11):5880. doi: 10.3390/ijms25115880.
6
Microbial-Related Metabolites May Be Involved in Eight Major Biological Processes and Represent Potential Diagnostic Markers in Gastric Cancer.微生物相关代谢产物可能参与八大主要生物学过程，并代表胃癌潜在的诊断标志物。
Cancers (Basel). 2023 Nov 3;15(21):5271. doi: 10.3390/cancers15215271.
本文引用的文献
1
Primary bile acid activates Egr‑1 expression through the MAPK signaling pathway in gastric cancer.初级胆汁酸通过 MAPK 信号通路激活胃癌中的 Egr-1 表达。
Mol Med Rep. 2022 Apr;25(4). doi: 10.3892/mmr.2022.12646. Epub 2022 Feb 16.
2
A comprehensive update: gastrointestinal microflora, gastric cancer and gastric premalignant condition, and intervention by traditional Chinese medicine.全面更新：胃肠道微生物群、胃癌和胃癌前病变，以及中药干预。
J Zhejiang Univ Sci B. 2022 Jan 15;23(1):1-18. doi: 10.1631/jzus.B2100182.
3
Metabolomics-Microbiome Crosstalk in the Breast Cancer Microenvironment.乳腺癌微环境中的代谢组学与微生物组相互作用
Metabolites. 2021 Nov 4;11(11):758. doi: 10.3390/metabo11110758.
4
Interactions between gastric microbiota and metabolites in gastric cancer.胃癌中胃微生物群和代谢物的相互作用。
Cell Death Dis. 2021 Nov 24;12(12):1104. doi: 10.1038/s41419-021-04396-y.
5
Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges.结直肠癌中肠道微生物群衍生的代谢产物：有害之处与挑战
Front Oncol. 2021 Oct 18;11:739648. doi: 10.3389/fonc.2021.739648. eCollection 2021.
6
Gut microbiota-derived metabolites in CRC progression and causation.结直肠肿瘤进展和病因中的肠道微生物衍生代谢物。
J Cancer Res Clin Oncol. 2021 Nov;147(11):3141-3155. doi: 10.1007/s00432-021-03729-w. Epub 2021 Jul 17.
7
High fat diet, gut microbiome and gastrointestinal cancer.高脂肪饮食、肠道微生物群与胃肠道癌症。
Theranostics. 2021 Apr 3;11(12):5889-5910. doi: 10.7150/thno.56157. eCollection 2021.
8
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
9
SNAIL regulates gastric carcinogenesis through CCN3 and NEFL.SNAIL 通过 CCN3 和 NEFL 调控胃癌发生。
Carcinogenesis. 2021 Feb 25;42(2):190-201. doi: 10.1093/carcin/bgaa133.
10
Cancer and the Microbiome-Influence of the Commensal Microbiota on Cancer, Immune Responses, and Immunotherapy.癌症与微生物组——共生微生物群对癌症、免疫反应和免疫治疗的影响。
Gastroenterology. 2021 Jan;160(2):600-613. doi: 10.1053/j.gastro.2020.11.041. Epub 2020 Nov 28.
Zotero 插件