Mentzel Thierry Q, Lieverse Ritsaert, Levens Amar, Mentzel Charlotte L, Tenback Diederik E, Bakker P Rob, Daanen Hein A M, van Harten Peter N
Psychiatric Centre GGz Centraal, Innova, Amersfoort, The Netherlands; Department of Psychiatry and Psychology, Maastricht University, Maastricht, The Netherlands.
Department of Psychiatry and Psychology, Maastricht University, Maastricht, The Netherlands.
Psychiatry Res. 2016 Apr 30;238:189-195. doi: 10.1016/j.psychres.2016.02.011. Epub 2016 Feb 17.
Bradykinesia is associated with reduced quality of life and medication non-compliance, and it may be a prodrome for schizophrenia. Therefore, screening/monitoring for subtle bradykinesia is of clinical and scientific importance. This study investigated the validity and reliability of such an instrument. Included were 70 patients with psychotic disorders. Inertial sensors captured mean cycle duration, amplitude and velocity of four movement tasks: walking, elbow flexion/extension, forearm pronation/supination and leg agility. The concurrent validity with the Unified Parkinson's Disease Rating Scale (UPDRS) bradykinesia subscale was determined using regression analysis. Reliability was investigated with the intra-class correlation coefficient. The duration, amplitude and velocities of the four tasks measured by the instrument explained 67% of the variance on the UPDRS bradykinesia subscale. The instrument test-retest reliability was high. The instrument investigated in this study is a valid and reliable alternative to observer-rated scales. It is an ideal tool for monitoring bradykinesia as it requires little training and experience to achieve reliable results.
运动迟缓与生活质量下降和药物治疗依从性差相关，并且可能是精神分裂症的前驱症状。因此，筛查/监测细微的运动迟缓具有临床和科学意义。本研究调查了这样一种工具的有效性和可靠性。纳入了70例精神障碍患者。惯性传感器记录了四项运动任务的平均周期时长、幅度和速度：行走、肘部屈伸、前臂旋前/旋后以及腿部敏捷性。使用回归分析确定与统一帕金森病评定量表（UPDRS）运动迟缓分量表的同时效度。使用组内相关系数研究可靠性。该仪器测量的四项任务的时长、幅度和速度解释了UPDRS运动迟缓分量表67%的方差。该仪器的重测信度很高。本研究中所调查的仪器是观察者评定量表的一种有效且可靠的替代方法。它是监测运动迟缓的理想工具，因为获得可靠结果几乎不需要培训和经验。
