Zekavat Omidreza, Amanat Aida, Karami Mohammadyasin, Paydar Shahram, Gramizadeh Bita, Zareian-Jahromi Maryam
Omidreza Zekavat, MD, is an Assistant Professor in the Department of Pediatrics Hematology and Oncology; Aida Amanat, MD, is a Medical Student; and Mohammadyasin Karami, MD, is a Medical Student; all at the Jahrom University of Medical Sciences in Jahrom, Fars, Iran. Shahram Paydar, MD, is an Assistant Professor in the Trauma Research Center, and Bita Gramizadeh, PhD, is a Professor in the Department of Pathology at Shiraz University of Medical Sciences in Shiraz, Fars, Iran. Maryam Zareian-Jahromi, MD, is a student of medicine at the Jahrom University of Medical Sciences in Jahrom, Fars, Iran.
Adv Skin Wound Care. 2016 May;29(5):217-25. doi: 10.1097/01.ASW.0000481116.16998.55.
The goal of the present study was to evaluate the effects of hydroalcoholic extract-based carboxy methyl cellulose (CMC) gel of Punica granatum peel (PCMC) and CMC on healing of full-thickness skin wounds.
Forty-two rats were studied. Each rat had 3 wounds that were treated topically with PCMC as the case, CMC as the positive control, and sterile saline as the negative control. All 3 wounds of each rat were photographed during the wound healing period at days 0 (onset of wound surgery), 3, 6, 9, and 12.The wound area was calculated using Adobe Photoshop CS (version 5) software (Adobe Systems Inc, San Jose, California). Electrocardiogram paper was used for reference scale.
The results of this study show that macroscopic and microscopic wound healing took a significantly longer time in wounds treated with normal saline than those treated with PCMC (grossly) and CMC gel (grossly and significantly).
The authors' findings show that anti-inflammatory, antihemorrhagic, and antinecrotic effects of CMC lead to early healing of skin wounds.
本研究的目的是评估基于石榴皮水醇提取物的羧甲基纤维素（CMC）凝胶（PCMC）和CMC对全层皮肤伤口愈合的影响。
对42只大鼠进行研究。每只大鼠有3处伤口，分别用PCMC（作为实验组）、CMC（作为阳性对照）和无菌生理盐水（作为阴性对照）进行局部处理。在伤口愈合期的第0天（伤口手术开始时）、第3天、第6天、第9天和第12天，对每只大鼠的所有3处伤口进行拍照。使用Adobe Photoshop CS（版本5）软件（Adobe Systems Inc，加利福尼亚州圣何塞）计算伤口面积。以心电图纸作为参考比例尺。
本研究结果表明，与用PCMC（肉眼观察）和CMC凝胶（肉眼观察且差异显著）处理的伤口相比，用生理盐水处理的伤口在宏观和微观层面的愈合时间明显更长。
作者的研究结果表明，CMC的抗炎、抗出血和抗坏死作用可促进皮肤伤口的早期愈合。
