Guyatt G H, Nogradi S, Halcrow S, Singer J, Sullivan M J, Fallen E L
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
J Gen Intern Med. 1989 Mar-Apr;4(2):101-7. doi: 10.1007/BF02602348.
The authors developed a new measure of subjective health status for patients with heart failure. Eighty-eight patients with heart failure were asked about the impact of their condition on 123 items related to physical and emotional function. The most frequently chosen and important items were included in a 16-item Chronic Heart Failure Questionnaire (CHQ) that examines dyspnea during daily activities, fatigue, and emotional function. The CHQ was tested in a controlled trial of digoxin in heart failure patients in sinus rhythm. When administered serially to 25 patients in the run-in phase of the trial, the CHQ proved reproducible. Subsequently, CHQ results distinguished those who reported improvement or deterioration from those who did not. The CHQ showed moderate correlations with patient global ratings, walk test scores, and clinical assessments of heart failure. The authors conclude that the CHQ may be useful for measuring health status in clinical trials in heart failure.
作者们为心力衰竭患者开发了一种新的主观健康状况衡量方法。88名心力衰竭患者被问及他们的病情对123项与身体和情感功能相关项目的影响。最常被选择且重要的项目被纳入一份16项的慢性心力衰竭问卷（CHQ），该问卷用于检查日常活动中的呼吸困难、疲劳和情感功能。CHQ在一项针对窦性心律心力衰竭患者使用地高辛的对照试验中进行了测试。在试验的导入期对25名患者连续使用时，CHQ被证明具有可重复性。随后，CHQ结果区分出了报告有改善或恶化的患者与未报告的患者。CHQ与患者的总体评分、步行测试分数以及心力衰竭的临床评估显示出中等程度的相关性。作者们得出结论，CHQ可能有助于在心力衰竭的临床试验中衡量健康状况。
