Zhou Min, Tian Mei, Li Chun
Departments of Cancer Systems Imaging The University of Texas M. D. Anderson Cancer Center 1881 East Road, Houston, Texas 77054, United States.
PET center, Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310009, China.
Bioconjug Chem. 2016 May 18;27(5):1188-99. doi: 10.1021/acs.bioconjchem.6b00156. Epub 2016 May 3.
Copper based nanoparticles (NPs) have attracted increased attention for biomedical applications. Copper chalcogenide NPs exhibit strong absorption in near-infrared region, demonstrate highly efficient light-to-heat transformation under near-infrared laser irradiation, and cause selective thermal destruction to the tumor. Smaller copper NPs display fluorescence signal and capability for optical imaging. Copper based NPs also serve as a versatile vehicle for drug delivery and image-guided therapy. This review covers recent advances related to the biomedical application of copper based NPs, with a focus on cancer imaging and therapy. We also discuss challenges to their successful clinical translation.
铜基纳米颗粒（NPs）在生物医学应用中已引起越来越多的关注。硫属铜化物纳米颗粒在近红外区域表现出强烈的吸收，在近红外激光照射下表现出高效的光热转换，并对肿瘤造成选择性热破坏。较小的铜纳米颗粒显示出荧光信号和光学成像能力。铜基纳米颗粒还可作为药物递送和图像引导治疗的通用载体。本综述涵盖了与铜基纳米颗粒生物医学应用相关的最新进展，重点是癌症成像和治疗。我们还讨论了它们成功临床转化面临的挑战。
