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Time to reconsider routine high-dose amoxicillin for community-acquired pneumonia in all Canadian children.是时候重新考虑在所有加拿大儿童中对社区获得性肺炎常规使用高剂量阿莫西林了。
Paediatr Child Health. 2016 Mar;21(2):65-6. doi: 10.1093/pch/21.2.65.
2
Comparative efficacy of amoxicillin, cefuroxime and clarithromycin in the treatment of community -acquired pneumonia in children.阿莫西林、头孢呋辛和克拉霉素治疗儿童社区获得性肺炎的疗效比较
J Coll Physicians Surg Pak. 2003 Dec;13(12):704-7.
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Comparative randomized trial of azithromycin versus erythromycin and amoxicillin for treatment of community-acquired pneumonia in children.阿奇霉素与红霉素及阿莫西林治疗儿童社区获得性肺炎的比较随机试验
Pediatr Pulmonol. 2003 Feb;35(2):91-8. doi: 10.1002/ppul.10180.
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Antibiotic use for community-acquired pneumonia in neonates and children: WHO evidence review.新生儿和儿童社区获得性肺炎的抗生素使用：世界卫生组织证据综述。
Paediatr Int Child Health. 2018 Nov;38(sup1):S66-S75. doi: 10.1080/20469047.2017.1409455.
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Oral versus i.v. antibiotics for community-acquired pneumonia in children: a cost-minimisation analysis.口服与静脉用抗生素治疗儿童社区获得性肺炎：成本最小化分析。
Eur Respir J. 2010 Apr;35(4):858-64. doi: 10.1183/09031936.00087209. Epub 2009 Aug 28.
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Efficacy of high doses of penicillin versus amoxicillin in the treatment of uncomplicated community acquired pneumonia in adults. A non-inferiority controlled clinical trial.大剂量青霉素与阿莫西林治疗成人社区获得性单纯性肺炎的疗效。一项非劣效性对照临床试验。
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Oral moxifloxacin vs high-dosage amoxicillin in the treatment of mild-to-moderate, community-acquired, suspected pneumococcal pneumonia in adults.口服莫西沙星与高剂量阿莫西林治疗成人轻至中度社区获得性疑似肺炎球菌肺炎的疗效比较
Chest. 2001 Jan;119(1):185-95. doi: 10.1378/chest.119.1.185.
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Double-blind, randomized study of the efficacy and safety of oral pharmacokinetically enhanced amoxicillin-clavulanate (2,000/125 milligrams) versus those of amoxicillin-clavulanate (875/125 milligrams), both given twice daily for 7 days, in treatment of bacterial community-acquired pneumonia in adults.口服药代动力学增强型阿莫西林-克拉维酸（2000/125毫克）与阿莫西林-克拉维酸（875/125毫克）治疗成人细菌性社区获得性肺炎的疗效和安全性的双盲随机研究，两者均每日给药两次，持续7天。
Antimicrob Agents Chemother. 2004 Sep;48(9):3323-31. doi: 10.1128/AAC.48.9.3323-3331.2004.
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Efficacy and safety of azithromycin 1 g once daily for 3 days in the treatment of community-acquired pneumonia: an open-label randomised comparison with amoxicillin-clavulanate 875/125 mg twice daily for 7 days.阿奇霉素1克每日一次，连用3天治疗社区获得性肺炎的疗效和安全性：与阿莫西林-克拉维酸875/125毫克每日两次，连用7天的开放标签随机对照研究。
J Chemother. 2008 Feb;20(1):77-86. doi: 10.1179/joc.2008.20.1.77.

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1
Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections Due to Extended-Spectrum Beta-Lactamase (ESBL)-Producing Klebsiella pneumoniae.克服抗生素耐药性：产超广谱β-内酰胺酶（ESBL）肺炎克雷伯菌引起的尿路感染使用高剂量阿莫西林克拉维酸。
Ann Transplant. 2023 May 16;28:e939258. doi: 10.12659/AOT.939258.
2
Community-acquired pneumonia among children: the latest evidence for an updated management.儿童社区获得性肺炎：更新管理的最新证据。
J Pediatr (Rio J). 2020 Mar-Apr;96 Suppl 1(Suppl 1):29-38. doi: 10.1016/j.jped.2019.08.003. Epub 2019 Sep 10.

本文引用的文献

1
Uncomplicated pneumonia in healthy Canadian children and youth: Practice points for management.健康加拿大儿童和青少年的非复杂性肺炎：管理要点
Paediatr Child Health. 2015 Nov-Dec;20(8):441-50. doi: 10.1093/pch/20.8.441.
2
Community-acquired pneumonia requiring hospitalization among U.S. children.美国儿童中需要住院治疗的社区获得性肺炎。
N Engl J Med. 2015 Feb 26;372(9):835-45. doi: 10.1056/NEJMoa1405870.
3
Incidence of viral infection detected by PCR and real-time PCR in childhood community-acquired pneumonia: a meta-analysis.聚合酶链反应（PCR）和实时荧光定量聚合酶链反应（real-time PCR）检测儿童社区获得性肺炎病毒感染的发生率：一项荟萃分析
Respirology. 2015 Apr;20(3):405-12. doi: 10.1111/resp.12472. Epub 2015 Jan 23.
4
Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication.阿莫西林的常见危害：针对任何适应症的随机安慰剂对照试验的系统评价和荟萃分析
CMAJ. 2015 Jan 6;187(1):E21-E31. doi: 10.1503/cmaj.140848. Epub 2014 Nov 17.
5
Epidemiology and etiology of childhood pneumonia in 2010: estimates of incidence, severe morbidity, mortality, underlying risk factors and causative pathogens for 192 countries.2010 年儿童肺炎的流行病学和病因学：192 个国家的发病率、严重发病、死亡率、潜在危险因素和病原体的估计。
J Glob Health. 2013 Jun;3(1):010401. doi: 10.7189/jogh.03.010401.
6
Pneumonia in healthy Canadian children and youth: Practice points for management.加拿大健康儿童和青少年的肺炎：管理实践要点
Paediatr Child Health. 2011 Aug;16(7):417-24. doi: 10.1093/pch/16.7.417.
7
Eradication of invasive pneumococcal disease due to the seven-valent pneumococcal conjugate vaccine serotypes in Calgary, Alberta.艾伯塔省卡尔加里市七种价肺炎球菌结合疫苗血清型所致侵袭性肺炎球菌病的消除。
Pediatr Infect Dis J. 2012 Sep;31(9):e169-75. doi: 10.1097/INF.0b013e3182624a40.
8
The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America.儿童社区获得性肺炎管理：儿童传染病学会和美国传染病学会临床实践指南（适用于 3 个月以上的婴儿和儿童）。
Clin Infect Dis. 2011 Oct;53(7):e25-76. doi: 10.1093/cid/cir531. Epub 2011 Aug 31.
9
Pneumococcal pneumonia and influenza: a deadly combination.肺炎球菌肺炎与流感：致命组合。
Vaccine. 2009 Aug 21;27 Suppl 3:C9-C14. doi: 10.1016/j.vaccine.2009.06.007.
10
Comprehensive detection of causative pathogens using real-time PCR to diagnose pediatric community-acquired pneumonia.使用实时聚合酶链反应全面检测致病病原体以诊断儿童社区获得性肺炎。
J Infect Chemother. 2008 Dec;14(6):424-32. doi: 10.1007/s10156-008-0648-6. Epub 2008 Dec 17.

Time to reconsider routine high-dose amoxicillin for community-acquired pneumonia in all Canadian children.

作者信息

Rajapakse Nipunie Srimalie, Vayalumkal Joseph Varkey, Vanderkooi Otto Gerben, Ricketson Leah Jeanne, Kellner James Duncan

机构信息

Section of Infectious Diseases, Department of Pediatrics, University of Calgary and Calgary Zone, Alberta Health Services;; Alberta Children's Hospital Research Institute (ACHRI);

Section of Infectious Diseases, Department of Pediatrics, University of Calgary and Calgary Zone, Alberta Health Services;; Alberta Children's Hospital Research Institute (ACHRI);; Calgary Streptococcus Pneumoniae Epidemiology Research Group (CASPER), Calgary, Alberta.

出版信息

Paediatr Child Health. 2016 Mar;21(2):65-6. doi: 10.1093/pch/21.2.65.

DOI:10.1093/pch/21.2.65
PMID:27095876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4807794/
Abstract
摘要