Klugman Keith P, Chien Yu-Wen, Madhi Shabir A
Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Vaccine. 2009 Aug 21;27 Suppl 3:C9-C14. doi: 10.1016/j.vaccine.2009.06.007.
Significant morbidity due to pneumococcal co-infection is associated with viral respiratory infections. Pneumonia is the leading cause of death in children worldwide. The incidence of clinical pneumonia among children in the United States decreased 39% following the introduction of a seven-valent pneumococcal conjugate vaccine (PCV). PCVs have also reduced hospitalisations associated with influenza in children. The majority of the mortality associated with the influenza pandemic of 1918 was attributable to bacterial infections, especially the pneumococcus. Vaccination with PCV for children and pneumococcal polysaccharide vaccine for adults should be considered essential to pandemic influenza preparedness.
肺炎球菌合并感染导致的严重发病与病毒性呼吸道感染有关。肺炎是全球儿童死亡的主要原因。在美国，引入七价肺炎球菌结合疫苗（PCV）后，儿童临床肺炎的发病率下降了39%。PCV还减少了儿童与流感相关的住院率。1918年流感大流行造成的死亡多数归因于细菌感染，尤其是肺炎球菌。应将儿童接种PCV和成人接种肺炎球菌多糖疫苗视为大流行性流感防范的必要措施。
