Department for Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department for Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Stress Research Institute, Stockholm University, Stockholm, Sweden Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden.
BMJ Open. 2016 Apr 25;6(4):e009440. doi: 10.1136/bmjopen-2015-009440.
Self-rated health is a powerful predictor of long-term health and mortality, hence the importance of a better understanding of its biological determinants. Previous studies have shown that low-grade inflammation is associated with poor self-rated health in clinical and healthy populations, but the evidence is sparse in men and completely lacking for men in late adolescence. The aim of this study was to investigate the association between low-grade inflammation and self-rated health among conscripts. It was hypothesised that high levels of inflammatory factors would be associated with poor self-rated health.
Data from 49,321 men (18-21 years) conscripted for military service in 1969 and 1970 were used. Inflammation had been measured through erythrocyte sedimentation rate (ESR). Self-rated health had been assessed on a five-point scale, and was dichotomised into Good ('Very good'/'Good'/'Fair') versus Poor ('Poor'/'Very poor'). Data from 43,110 conscripts with normal levels of ESR, and who reported self-rated health remained after exclusion of those with ESR <1 and >11 mm/h. Associations were calculated using logistic regression analyses. Adjustments were made for body mass index, socioeconomic position, inflammatory disease, emotion regulation, smoking, risky use of alcohol and physical activity.
High levels of ESR were associated with higher odds for poor self-rated health (OR: 1.077 for each unit mm/h increase in ESR, 95% CI 1.049 to 1.105).
The present study shows for the first time a significant association between a marker of inflammation and self-rated health in late adolescent men, adding to evidence of an association between low-grade inflammation and subjective health perception also in men, as previously demonstrated in women. Further support for inflammation as part of a general psychobiological process that underpins subjective health perception is hereby provided.
自评健康是长期健康和死亡率的有力预测指标，因此更好地了解其生物学决定因素非常重要。先前的研究表明，低水平炎症与临床和健康人群的自评健康不良有关，但在男性中的证据很少，在青春期后期的男性中则完全缺乏。本研究旨在调查应征者中低度炎症与自评健康之间的关系。假设炎症因子水平高与自评健康不良有关。
使用了 1969 年和 1970 年应征入伍的 49321 名男性（18-21 岁）的数据。通过红细胞沉降率（ESR）测量炎症。自评健康通过五分制进行评估，并分为良好（“非常好”/“好”/“尚可”）和不良（“差”/“非常差”）。排除 ESR<1 和>11mm/h 的人群后，对 ESR 水平正常且报告自评健康的 43110 名应征者的数据进行了分析。使用逻辑回归分析计算关联。调整了体重指数、社会经济地位、炎症性疾病、情绪调节、吸烟、饮酒风险和身体活动。
ESR 水平升高与自评健康不良的几率增加相关（ESR 每增加 1mm/h，OR：1.077，95%CI 1.049 至 1.105）。
本研究首次表明，炎症标志物与青春期后期男性自评健康之间存在显著关联，进一步证明了低度炎症与主观健康感知之间的关联，这在以前的女性研究中已有证实。为炎症作为主观健康感知的一般心理生物学过程的一部分提供了进一步的支持。
